Analyzing and Tuning Ribozyme Activity by Deep Sequencing To Modulate Gene Expression Level in Mammalian Cells

January 24th, 2018 by Shungo Kobori and Yohei Yokobayashi

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00367
  • Posted in ACS Synthetic Biology, Publications
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Applications are Invited for Head of the Department of Biochemistry and Biophysics at Texas A&M University

January 24th, 2018 by pthomas2

Applications are invited for the position of Head of the Department of Biochemistry and Biophysics at Texas A&M University. An ideal candidate should have an internationally recognized research program, a demonstrated commitment to undergraduate and graduate education, significant administrative experience and visionary leadership. The position requires a Ph.D. in the biological sciences or a related field, with a record of distinction in research, teaching, and service.

For more information, see the attached PDF.

Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair

January 22nd, 2018 by Naoyuki Uchida

Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair

Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair, Published online: 22 January 2018; doi:10.1038/nchembio.2555

A synthetic, orthogonal pair of the plant hormone auxin and its receptor TIR1 was engineered to hijack auxin signaling without interfering with the endogenous system. The synthetic system conclusively demonstrates the role for TIR1 in auxin-induced acid growth.
  • Posted in Nat Chem Biol, Publications
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A whole-animal platform to advance a clinical kinase inhibitor into new disease space

January 22nd, 2018 by Masahiro Sonoshita

A whole-animal platform to advance a clinical kinase inhibitor into new disease space

A whole-animal platform to advance a clinical kinase inhibitor into new disease space, Published online: 22 January 2018; doi:10.1038/nchembio.2556

Combining Drosophila genetics with chemistry and computation led to the development of novel kinase inhibitors based on the RAF-targeting drug sorafenib that reveal the RET oncogene as an enhancer of drug action and improve the therapeutic window in medullary thyroid carcinoma models.
  • Posted in Nat Chem Biol, Publications
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MinGenome: An In Silico Top-Down Approach for the Synthesis of Minimized Genomes

January 20th, 2018 by Lin Wang and Costas D. Maranas

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00296

Natural products: Tapping into personalized chemistry

January 16th, 2018 by Jack R Davison

Natural products: Tapping into personalized chemistry

Natural products: Tapping into personalized chemistry, Published online: 16 January 2018; doi:10.1038/nchembio.2560

By integrating metagenomics, spectroscopy and synthetic biology, the individualized chemistry of small reef-dwelling organisms and their associated microbiota can be characterized in exquisite detail, unlocking a wealth of structural diversity for the development of new drugs.

Synthetic biology: License to kill

January 16th, 2018 by Caitlin Deane

Synthetic biology: License to kill

Synthetic biology: License to kill, Published online: 16 January 2018; doi:10.1038/nchembio.2561

Synthetic biology: License to kill

Errata: Continuous directed evolution of aminoacyl-tRNA synthetases

January 16th, 2018 by David I Bryson

Errata: Continuous directed evolution of aminoacyl-tRNA synthetases

Errata: Continuous directed evolution of aminoacyl-tRNA synthetases, Published online: 16 January 2018; doi:10.1038/nchembio0218-186

Errata: Continuous directed evolution of aminoacyl-tRNA synthetases

Drug development: Allosteric inhibitors hit USP7 hard

January 16th, 2018 by Wei Zhang

Drug development: Allosteric inhibitors hit USP7 hard

Drug development: Allosteric inhibitors hit USP7 hard, Published online: 16 January 2018; doi:10.1038/nchembio.2557

A potent and specific small-molecule inhibitor of a long-sought-after anticancer drug target, USP7, that acts allosterically to inhibit MDM2-stabilizing activity foretells of more allosteric inhibitors for deubiquitinases and E3 ligases.

RNA Splicing: Making the cut

January 16th, 2018 by Stéphane Larochelle

RNA Splicing: Making the cut

RNA Splicing: Making the cut, Published online: 16 January 2018; doi:10.1038/nchembio.2564

RNA Splicing: Making the cut