Dynamic coupling between conformations and nucleotide states in DNA gyrase

April 16th, 2018 by Aakash Basu

Dynamic coupling between conformations and nucleotide states in DNA gyrase

Dynamic coupling between conformations and nucleotide states in DNA gyrase, Published online: 16 April 2018; doi:10.1038/s41589-018-0037-0

Single-molecule measurements of DNA gyrase activity reveal conformational dynamics coupling ATP consumption to DNA supercoiling.
  • Posted in Nat Chem Biol, Publications
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Structure in sequence

April 16th, 2018 by Yiyun Song

Structure in sequence

Structure in sequence, Published online: 16 April 2018; doi:10.1038/s41589-018-0050-3

Structure in sequence

The peptide <span class=”small-caps”>d</span>-list

April 16th, 2018 by Mirella Bucci

The peptide d-list

The peptide <span class="small-caps">d</span>-list, Published online: 16 April 2018; doi:10.1038/s41589-018-0049-9

The peptide d-list

Fueled by light

April 16th, 2018 by Grant Miura

Fueled by light

Fueled by light, Published online: 16 April 2018; doi:10.1038/s41589-018-0048-x

Fueled by light

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic

April 16th, 2018 by Marina Santiago

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic, Published online: 16 April 2018; doi:10.1038/s41589-018-0041-4

Use of a combined Tn-seq and machine-learning approach for predicting mechanisms and targets of antibiotic action in Staphylococcus aureus shows that the natural product lysocin E (LysE) binds Lipid II on the cell surface and damages the membrane.
  • Posted in Nat Chem Biol, Publications
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Spotting the signal

April 16th, 2018 by Caitlin Deane

Spotting the signal

Spotting the signal, Published online: 16 April 2018; doi:10.1038/s41589-018-0047-y

Spotting the signal

[ASAP] Second-Shell Hydrogen Bond Impacts Transition-State Structure in <italic toggle=”yes”>Bacillus subtilis</italic> Oxalate Decarboxylase

April 11th, 2018 by Wen Zhu, Laurie A. Reinhardt, Nigel G. J. Richards

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b00214

Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes

April 2nd, 2018 by Simon Wisnovsky

Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes

Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes, Published online: 02 April 2018; doi:10.1038/s41589-018-0040-5

Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes
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The structural organization of substrate loading in iterative polyketide synthases

April 2nd, 2018 by Dominik A. Herbst

The structural organization of substrate loading in iterative polyketide synthases

The structural organization of substrate loading in iterative polyketide synthases, Published online: 02 April 2018; doi:10.1038/s41589-018-0026-3

The crystal structure and cryo-electron microscopy of the loading/condensing region of a nonreducing polyketide synthase reveals the insertion of a starter-unit acyltransferase into the condensing region and an asymmetrical post-loading state.
  • Posted in Nat Chem Biol, Publications
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Super-long single-molecule tracking reveals dynamic-anchorage-induced integrin function

April 2nd, 2018 by Taka A. Tsunoyama

Super-long single-molecule tracking reveals dynamic-anchorage-induced integrin function

Super-long single-molecule tracking reveals dynamic-anchorage-induced integrin function, Published online: 02 April 2018; doi:10.1038/s41589-018-0032-5

Dissolved oxygen and a reducing-plus-oxidizing system suppress photobleaching and photoblinking in single-molecule tracking experiments, allowing long recordings of CD47 and integrin that showed temporary immobilization within focal adhesions.
  • Posted in Nat Chem Biol, Publications
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