Host–microbe interactions: Inflammation sop-up

May 18th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2095

Author: Mirella Bucci

Designing convergent chemistry curricula

May 18th, 2016 by Louise K Charkoudian

Nature Chemical Biology 12, 382 (2016). doi:10.1038/nchembio.2090

Authors: Louise K Charkoudian, Nicole S Sampson, Krishna Kumar & Joshua A Kritzer

Scientific convergence is a common theme of modern research, but undergraduate chemistry is commonly taught as an isolated discipline. Here we discuss curricular updates at three different institutions that are independently seeking to increase convergence in introductory chemistry courses.

Gene expression: Means to an end

May 18th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2093

Author: Terry L. Sheppard

Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase

May 16th, 2016 by Lisandro J González

Nature Chemical Biology 12, 516 (2016). doi:10.1038/nchembio.2083

Authors: Lisandro J González, Guillermo Bahr, Toshiki G Nakashige, Elizabeth M Nolan, Robert A Bonomo & Alejandro J Vila

  • Posted in Nat Chem Biol, Publications
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A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes

May 16th, 2016 by Monique P C Mulder

Nature Chemical Biology 12, 523 (2016). doi:10.1038/nchembio.2084

Authors: Monique P C Mulder, Katharina Witting, Ilana Berlin, Jonathan N Pruneda, Kuen-Phon Wu, Jer-Gung Chang, Remco Merkx, Johanna Bialas, Marcus Groettrup, Alfred C O Vertegaal, Brenda A Schulman, David Komander, Jacques Neefjes, Farid El Oualid & Huib Ovaa

  • Posted in Nat Chem Biol, Publications
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The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α

May 16th, 2016 by Ting Han

Nature Chemical Biology 12, 511 (2016). doi:10.1038/nchembio.2082

Authors: Ting Han, Maria Goralski, Emanuela Capota, Shae B Padrick, Jiwoong Kim, Yang Xie & Deepak Nijhawan

Supervised Learning in Adaptive DNA Strand Displacement Networks

May 11th, 2016 by Matthew R. Lakin and Darko Stefanovic

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.6b00009

Repurposing Synechocystis PCC6803 UirS–UirR as a UV-Violet/Green Photoreversible Transcriptional Regulatory Tool in E. coli

May 11th, 2016 by Prabha Ramakrishnan and Jeffrey J. Tabor

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.6b00068
  • Posted in ACS Synthetic Biology, Publications
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Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

May 9th, 2016 by Sara Sdelci

Nature Chemical Biology 12, 504 (2016). doi:10.1038/nchembio.2080

Authors: Sara Sdelci, Charles-Hugues Lardeau, Cynthia Tallant, Freya Klepsch, Björn Klaiber, James Bennett, Philipp Rathert, Michael Schuster, Thomas Penz, Oleg Fedorov, Giulio Superti-Furga, Christoph Bock, Johannes Zuber, Kilian V M Huber, Stefan Knapp, Susanne Müller & Stefan Kubicek

  • Posted in Nat Chem Biol, Publications
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Prdm4 induction by the small molecule butein promotes white adipose tissue browning

May 9th, 2016 by No-Joon Song

Nature Chemical Biology 12, 479 (2016). doi:10.1038/nchembio.2081

Authors: No-Joon Song, Seri Choi, Prashant Rajbhandari, Seo-Hyuk Chang, Suji Kim, Laurent Vergnes, So-Mi Kwon, Jung-Hoon Yoon, Sukchan Lee, Jin-Mo Ku, Jeong-Soo Lee, Karen Reue, Seung-Hoi Koo, Peter Tontonoz & Kye Won Park

Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

  • Posted in Nat Chem Biol, Publications
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