[ASAP] Synthetic Transcription Factors Switch from Local to Long-Range Control during Cell Differentiation

January 17th, 2019 by Takeo Wada, Sandrine Wallerich, Attila Becskei

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00369
  • Posted in ACS Synthetic Biology, Publications
  • Comments Off on [ASAP] Synthetic Transcription Factors Switch from Local to Long-Range Control during Cell Differentiation

[ASAP] Targeting Type 1 Diabetes: Selective Approaches for New Therapies

January 17th, 2019 by Daniel F. Sheehy, Sean P. Quinnell, Arturo J. Vegas

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b01118

[ASAP] Retro Styles for Vesicle Coats

January 17th, 2019 by James H. Hurley, Ludger Johannes

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b01271

[ASAP] An Artificial Pathway for Isoprenoid Biosynthesis Decoupled from Native Hemiterpene Metabolism

January 16th, 2019 by Sean Lund, Rachael Hall, Gavin J Williams

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00383
  • Posted in ACS Synthetic Biology, Publications
  • Comments Off on [ASAP] An Artificial Pathway for Isoprenoid Biosynthesis Decoupled from Native Hemiterpene Metabolism

Discovery of a ZIP7 inhibitor from a Notch pathway screen

January 14th, 2019 by Erin Nolin

Discovery of a ZIP7 inhibitor from a Notch pathway screen

Discovery of a ZIP7 inhibitor from a Notch pathway screen, Published online: 14 January 2019; doi:10.1038/s41589-018-0200-7

A cell-based phenotypic screen identifying inhibitors of Notch signaling led to the discovery of NVS-ZP7-4, which blocks the activity of the zinc transporter SLC39a7 (ZIP7) and induces cell death through an ER stress mechanism.

A chemical–genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase

January 14th, 2019 by Dhanashree S. Kelkar

A chemical–genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase

A chemical–genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase, Published online: 14 January 2019; doi:10.1038/s41589-018-0195-0

Screening with a small-molecule reactive-oxygen-species generator identifies the serine hydrolase enzyme ABHD12 as a lipase for the proapoptotic oxidized phoshatidylserine (ox-PS) lipids, which trigger production of proinflammatory cytokines.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on A chemical–genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase

Fast bioelectrical switches

January 14th, 2019 by Michaela TerAvest

Fast bioelectrical switches

Fast bioelectrical switches, Published online: 14 January 2019; doi:10.1038/s41589-018-0212-3

Faster-than-transcription control of cellular activities is an important but challenging engineering target. Using split ferredoxins and induced dimerization or conformational changes, newly developed metalloprotein switches provide a fast method to control electron flux.

Complete reconstitution of the diverse pathways of gentamicin B biosynthesis

January 14th, 2019 by Yeon Hee Ban

Complete reconstitution of the diverse pathways of gentamicin B biosynthesis

Complete reconstitution of the diverse pathways of gentamicin B biosynthesis, Published online: 14 January 2019; doi:10.1038/s41589-018-0203-4

The reconstitution of gentamicin B biosynthesis reveals the existence of multiple new intermediates and branching pathways and enables the identification of factors that contribute to the low levels of the natural product in the native producer.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on Complete reconstitution of the diverse pathways of gentamicin B biosynthesis

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

January 14th, 2019 by Naoya Shindo

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides, Published online: 14 January 2019; doi:10.1038/s41589-018-0204-3

Discovery and exploitation of inherent reaction features of chlorofluoroacetamide (CFA) as a warhead such as low off-target activity and reversible reactivity with cysteine enable specific covalent inhibition of targeted kinases.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

IFITM3 directly engages and shuttles incoming virus particles to lysosomes

January 14th, 2019 by Jennifer S. Spence

IFITM3 directly engages and shuttles incoming virus particles to lysosomes

IFITM3 directly engages and shuttles incoming virus particles to lysosomes, Published online: 14 January 2019; doi:10.1038/s41589-018-0213-2

Live-cell imaging and virus trafficking studies show that the host innate immune receptor IFITM3 localizes with endocytic vesicles that fuse with incoming viruses to ultimately enhance their traffic to lysosomes.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on IFITM3 directly engages and shuttles incoming virus particles to lysosomes