Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

March 28th, 2016 by Richard M Deans

Nature Chemical Biology 12, 361 (2016). doi:10.1038/nchembio.2050

Authors: Richard M Deans, David W Morgens, Ayşe Ökesli, Sirika Pillay, Max A Horlbeck, Martin Kampmann, Luke A Gilbert, Amy Li, Roberto Mateo, Mark Smith, Jeffrey S Glenn, Jan E Carette, Chaitan Khosla & Michael C Bassik

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs

March 28th, 2016 by William H Parsons

Nature Chemical Biology 12, 367 (2016). doi:10.1038/nchembio.2051

Authors: William H Parsons, Matthew J Kolar, Siddhesh S Kamat, Armand B Cognetta III, Jonathan J Hulce, Enrique Saez, Barbara B Kahn, Alan Saghatelian & Benjamin F Cravatt

  • Posted in Nat Chem Biol, Publications
  • Comments Off on AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs

Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling

March 28th, 2016 by Geoffrey A Smith

Nature Chemical Biology 12, 373 (2016). doi:10.1038/nchembio.2056

Authors: Geoffrey A Smith, Kenji Uchida, Arthur Weiss & Jack Taunton

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling

2016 Philadelphia ACS Meeting BIOL Division ABSTRACT DEADLINE – EXTENDED!

March 22nd, 2016 by pthomas2

The Fall ACS meeting will be Aug 21-25 in Philadelphia. You can now submit abstracts through the ACS MAPS system: maps.acs.orgDeadline for BIOL abstracts has been extended to March 28.  Program Chairs are Vahe Bandarian and Lizbeth Hedstrom.

BIOL Division Nominees Sought for the Kavli Emerging Leader Lecturer in Chemistry

March 21st, 2016 by pthomas2

The Kavli Foundation Emerging Leader in Chemistry Lecture is awarded to an outstanding chemical scientist who is less than 10 years past receipt of his or her Ph.D. and will be under 40 years of age as of Monday, April 3, 2017, the date of the lecture. The ninth lecture in this series will take place at the Spring ACS National Meeting in San Francisco, CA. Divisional nominations must be submitted to the ACS after approval from the respective division Chair. The deadline for BIOL Chair approval is April 4, 2016. Complete nomination materials must be submitted to the ACS by April 11, 2016 for consideration. Contact the BIOL Division Chair, Prof. Dewey G. McCafferty, for additional information and nomination forms: dewey.mccafferty@duke.edu

Chemically Modifying Viruses for Diverse Applications

March 21st, 2016 by Kritika Mohan and Gregory A. Weiss

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.6b00060

Why Nature Chose Selenium

March 21st, 2016 by Hans J. Reich and Robert J. Hondal

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.6b00031

Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage

March 21st, 2016 by Ling Liu

Nature Chemical Biology 12, 345 (2016). doi:10.1038/nchembio.2047

Authors: Ling Liu, Supriya Shah, Jing Fan, Junyoung O Park, Kathryn E Wellen & Joshua D Rabinowitz

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage

Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis

March 21st, 2016 by Yi Xiao

Nature Chemical Biology 12, 339 (2016). doi:10.1038/nchembio.2046

Authors: Yi Xiao, Christopher H Bowen, Di Liu & Fuzhong Zhang

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis

Steric trapping reveals a cooperativity network in the intramembrane protease GlpG

March 21st, 2016 by Ruiqiong Guo

Nature Chemical Biology 12, 353 (2016). doi:10.1038/nchembio.2048

Authors: Ruiqiong Guo, Kristen Gaffney, Zhongyu Yang, Miyeon Kim, Suttipun Sungsuwan, Xuefei Huang, Wayne L Hubbell & Heedeok Hong

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Steric trapping reveals a cooperativity network in the intramembrane protease GlpG