Metalloproteins: Mapping elusive electron density

May 18th, 2016 by Louis Noodleman

Nature Chemical Biology 12, 391 (2016). doi:10.1038/nchembio.2088

Author: Louis Noodleman

Iron–sulfur metalloproteins are critical for electron transfer in bacterial metabolism, but most crystal structures are insufficient for their in-depth study. Now, acquisition of an iron–sulfur protein structure at ultra-high resolution enables detailed visualization of its electron distribution.

Proteostasis: Chaperoning for hearing loss

May 18th, 2016 by Gergely L Lukacs

Nature Chemical Biology 12, 388 (2016). doi:10.1038/nchembio.2091

Author: Gergely L Lukacs

A small molecule has been identified that can mitigate the progression of an inherited form of deafness in transgenic mice by stabilizing mutant clarin-1, an essential component of a multimolecular complex of the mechanotransduction apparatus of hair cells in the inner ear.

Protein evolution: Polymerase’s new language

May 18th, 2016 by Caitlin Deane

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2094

Author: Caitlin Deane

Genomics: A Tribe for RNA

May 18th, 2016 by Grant Miura

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2092

Author: Grant Miura

Host–microbe interactions: Inflammation sop-up

May 18th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2095

Author: Mirella Bucci

Designing convergent chemistry curricula

May 18th, 2016 by Louise K Charkoudian

Nature Chemical Biology 12, 382 (2016). doi:10.1038/nchembio.2090

Authors: Louise K Charkoudian, Nicole S Sampson, Krishna Kumar & Joshua A Kritzer

Scientific convergence is a common theme of modern research, but undergraduate chemistry is commonly taught as an isolated discipline. Here we discuss curricular updates at three different institutions that are independently seeking to increase convergence in introductory chemistry courses.

Gene expression: Means to an end

May 18th, 2016 by Terry L. Sheppard

Nature Chemical Biology 12, 387 (2016). doi:10.1038/nchembio.2093

Author: Terry L. Sheppard

Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase

May 16th, 2016 by Lisandro J González

Nature Chemical Biology 12, 516 (2016). doi:10.1038/nchembio.2083

Authors: Lisandro J González, Guillermo Bahr, Toshiki G Nakashige, Elizabeth M Nolan, Robert A Bonomo & Alejandro J Vila

  • Posted in Nat Chem Biol, Publications
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A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes

May 16th, 2016 by Monique P C Mulder

Nature Chemical Biology 12, 523 (2016). doi:10.1038/nchembio.2084

Authors: Monique P C Mulder, Katharina Witting, Ilana Berlin, Jonathan N Pruneda, Kuen-Phon Wu, Jer-Gung Chang, Remco Merkx, Johanna Bialas, Marcus Groettrup, Alfred C O Vertegaal, Brenda A Schulman, David Komander, Jacques Neefjes, Farid El Oualid & Huib Ovaa

  • Posted in Nat Chem Biol, Publications
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The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α

May 16th, 2016 by Ting Han

Nature Chemical Biology 12, 511 (2016). doi:10.1038/nchembio.2082

Authors: Ting Han, Maria Goralski, Emanuela Capota, Shae B Padrick, Jiwoong Kim, Yang Xie & Deepak Nijhawan