Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds

May 30th, 2016 by Giancarlo Bruni

Nature Chemical Biology 12, 559 (2016). doi:10.1038/nchembio.2097

Authors: Giancarlo Bruni, Andrew J Rennekamp, Andrea Velenich, Matthew McCarroll, Leo Gendelev, Ethan Fertsch, Jack Taylor, Parth Lakhani, Dennis Lensen, Tama Evron, Paul J Lorello, Xi-Ping Huang, Sabine Kolczewski, Galen Carey, Barbara J Caldarone, Eric Prinssen, Bryan L Roth, Michael J Keiser, Randall T Peterson & David Kokel

  • Posted in Nat Chem Biol, Publications
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Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes

May 30th, 2016 by Simon Wisnovsky

Nature Chemical Biology 12, 567 (2016). doi:10.1038/nchembio.2102

Authors: Simon Wisnovsky, Sae Rin Jean & Shana O Kelley

  • Posted in Nat Chem Biol, Publications
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pH-Dependent DNA Distortion and Repression of Gene Expression by Pectobacterium atrosepticum PecS

May 27th, 2016 by Dinesh K. Deochand, Jacob K. Meariman and Anne Grove

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ACS Chemical Biology
DOI: 10.1021/acschembio.6b00168
  • Posted in ACS Chemical Biology, Publications
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Advances in Enzymatic Glycoside Synthesis

May 26th, 2016 by Phillip M. Danby and Stephen G. Withers

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.6b00340

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

May 23rd, 2016 by Maia Vinogradova

Nature Chemical Biology 12, 531 (2016). doi:10.1038/nchembio.2085

Authors: Maia Vinogradova, Victor S Gehling, Amy Gustafson, Shilpi Arora, Charles A Tindell, Catherine Wilson, Kaylyn E Williamson, Gulfem D Guler, Pranoti Gangurde, Wanda Manieri, Jennifer Busby, E Megan Flynn, Fei Lan, Hyo-jin Kim, Shobu Odate, Andrea G Cochran, Yichin Liu, Matthew Wongchenko, Yibin Yang, Tommy K Cheung, Tobias M Maile, Ted Lau, Michael Costa, Ganapati V Hegde, Erica Jackson, Robert Pitti, David Arnott, Christopher Bailey, Steve Bellon, Richard T Cummings, Brian K Albrecht, Jean-Christophe Harmange, James R Kiefer, Patrick Trojer & Marie Classon

  • Posted in Nat Chem Biol, Publications
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NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNAMet

May 23rd, 2016 by Saori Nakano

Nature Chemical Biology 12, 546 (2016). doi:10.1038/nchembio.2099

Authors: Saori Nakano, Takeo Suzuki, Layla Kawarada, Hiroyoshi Iwata, Kana Asano & Tsutomu Suzuki

  • Posted in Nat Chem Biol, Publications
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Structural analysis of human KDM5B guides histone demethylase inhibitor development

May 23rd, 2016 by Catrine Johansson

Nature Chemical Biology 12, 539 (2016). doi:10.1038/nchembio.2087

Authors: Catrine Johansson, Srikannathasan Velupillai, Anthony Tumber, Aleksandra Szykowska, Edward S Hookway, Radoslaw P Nowak, Claire Strain-Damerell, Carina Gileadi, Martin Philpott, Nicola Burgess-Brown, Na Wu, Jola Kopec, Andrea Nuzzi, Holger Steuber, Ursula Egner, Volker Badock, Shonagh Munro, Nicholas B LaThangue, Sue Westaway, Jack Brown, Nick Athanasou, Rab Prinjha, Paul E Brennan & Udo Oppermann

  • Posted in Nat Chem Biol, Publications
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Lighting the way

May 18th, 2016 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology 12, 381 (2016). doi:10.1038/nchembio.2101

The innovation and optimization of optogenetic tools are providing new insights into biological and cellular processes with unparalleled spatiotemporal resolution.

Erratum: Chemoproteomic profiling of host and pathogen enzymes active in cholera

May 18th, 2016 by Stavroula K Hatzios

Nature Chemical Biology 12, 466 (2016). doi:10.1038/nchembio0616-466

Author: Stavroula K Hatzios, Sören Abel, Julianne Martell, Troy Hubbard, Jumpei Sasabe, Diana Munera, Lars Clark, Daniel A Bachovchin, Firdausi Qadri, Edward T Ryan, Brigid M Davis, Eranthie Weerapana & Matthew K Waldor

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Cancer metabolism: Addicted to serine

May 18th, 2016 by Christian Frezza

Nature Chemical Biology 12, 389 (2016). doi:10.1038/nchembio.2086

Author: Christian Frezza

Phosphoglycerate dehydrogenase (PHGDH) is an enzyme of serine biosynthesis overexpressed in various types of cancer. A new series of PHGDH inhibitors selectively block proliferation of PHGDH-dependent cancer cells and reveal an unexpected role of serine biosynthesis in coordinating one-carbon metabolism.