RNA structure: Know when to fold ’em

November 15th, 2016 by Grant Miura

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2255

Author: Grant Miura

Drug discovery: Doubling down on BET inhibition

November 15th, 2016 by Dafydd Owen

Nature Chemical Biology 12, 991 (2016). doi:10.1038/nchembio.2242

Author: Dafydd Owen

Through simultaneous binding to more than one site in a single protein, multivalent small molecules can achieve huge increases in potency. This 'avidity effect' has been demonstrated in BET bromodomain-containing proteins with bivalent probes that represent some of the most potent BET inhibitors to date.

Epigenomics: Massive ATAC

November 15th, 2016 by Joshua M. Finkelstein

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2257

Author: Joshua M. Finkelstein

Protein synthesis: Breaking down the NSA1

November 15th, 2016 by Grant Miura

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2258

Author: Grant Miura

Immunology: T cells get L-ARGed

November 15th, 2016 by Mirella Bucci

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2256

Author: Mirella Bucci

Photosynthesis: Short circuit at the chlorophyll

November 15th, 2016 by Marc M Nowaczyk

Nature Chemical Biology 12, 990 (2016). doi:10.1038/nchembio.2240

Authors: Marc M Nowaczyk & Nicolas Plumeré

Interfacing photosynthetic proteins and electrodes for investigating light-induced charge separation remains challenging. The discovery of a competing charge transfer pathway through the light-harvesting antenna defines new design requirements for electrode modification.

Nuclear receptors: PPARα ligands make memories

November 15th, 2016 by Thomas P Burris

Nature Chemical Biology 12, 993 (2016). doi:10.1038/nchembio.2241

Author: Thomas P Burris

Three newly identified endogenous ligands of the nuclear receptor PPARα—hydroxydimethylbutyrate, hexadecanamide and octadecenamide—are implicated in the noncanonical activity of PPARα in synaptic function and hippocampal plasticity.

Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase

November 15th, 2016 by Tiyun Han, Quan Chen and Haiyan Liu

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.6b00248

Identification of a Novel Activator of Mammalian Glutamate Dehydrogenase

November 14th, 2016 by Hong Q. Smith and Thomas J. Smith

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DOI: 10.1021/acs.biochem.6b00979

Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution

November 14th, 2016 by Ryan S Nett

Nature Chemical Biology 13, 69 (2017). doi:10.1038/nchembio.2232

Authors: Ryan S Nett, Mariana Montanares, Ariana Marcassa, Xuan Lu, Raimund Nagel, Trevor C Charles, Peter Hedden, Maria Cecilia Rojas & Reuben J Peters

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