The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme

February 13th, 2017 by Jamie L Bingaman

Nature Chemical Biology 13, 439 (2017). doi:10.1038/nchembio.2300

Authors: Jamie L Bingaman, Sixue Zhang, David R Stevens, Neela H Yennawar, Sharon Hammes-Schiffer & Philip C Bevilacqua

  • Posted in Nat Chem Biol, Publications
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Evolution of a split RNA polymerase as a versatile biosensor platform

February 13th, 2017 by Jinyue Pu

Nature Chemical Biology 13, 432 (2017). doi:10.1038/nchembio.2299

Authors: Jinyue Pu, Julia Zinkus-Boltz & Bryan C Dickinson

  • Posted in Nat Chem Biol, Publications
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An orthogonalized platform for genetic code expansion in both bacteria and eukaryotes

February 13th, 2017 by James S Italia

Nature Chemical Biology 13, 446 (2017). doi:10.1038/nchembio.2312

Authors: James S Italia, Partha Sarathi Addy, Chester J J Wrobel, Lisa A Crawford, Marc J Lajoie, Yunan Zheng & Abhishek Chatterjee

  • Posted in Nat Chem Biol, Publications
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AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons

February 13th, 2017 by Kirill Gorshkov

Nature Chemical Biology 13, 425 (2017). doi:10.1038/nchembio.2298

Authors: Kirill Gorshkov, Sohum Mehta, Santosh Ramamurthy, Gabriele V Ronnett, Feng-Quan Zhou & Jin Zhang

  • Posted in Nat Chem Biol, Publications
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Selective in vivo metabolic cell-labeling-mediated cancer targeting

February 13th, 2017 by Hua Wang

Nature Chemical Biology 13, 415 (2017). doi:10.1038/nchembio.2297

Authors: Hua Wang, Ruibo Wang, Kaimin Cai, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou, Qian Yin, Li Tang, Iwona T Dobrucki, Lawrence W Dobrucki, Eric J Chaney, Stephen A Boppart, Timothy M Fan, Stéphane Lezmi, Xuesi Chen, Lichen Yin & Jianjun Cheng

CipA and CipB as Scaffolds To Organize Proteins into Crystalline Inclusions

February 10th, 2017 by Yang Wang, Ralf Heermann and Kirsten Jung

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.6b00323

Structure and specificity of a permissive bacterial C-prenyltransferase

February 6th, 2017 by Sherif I Elshahawi

Nature Chemical Biology 13, 366 (2017). doi:10.1038/nchembio.2285

Authors: Sherif I Elshahawi, Hongnan Cao, Khaled A Shaaban, Larissa V Ponomareva, Thangaiah Subramanian, Mark L Farman, H Peter Spielmann, George N Phillips, Jon S Thorson & Shanteri Singh

This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.

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A tight tunable range for Ni(II) sensing and buffering in cells

February 6th, 2017 by Andrew W Foster

Nature Chemical Biology 13, 409 (2017). doi:10.1038/nchembio.2310

Authors: Andrew W Foster, Rafael Pernil, Carl J Patterson, Andrew J P Scott, Lars-Olof Pålsson, Robert Pal, Ian Cummins, Peter T Chivers, Ehmke Pohl & Nigel J Robinson

A water-mediated allosteric network governs activation of Aurora kinase A

February 6th, 2017 by Soreen Cyphers

Nature Chemical Biology 13, 402 (2017). doi:10.1038/nchembio.2296

Authors: Soreen Cyphers, Emily F Ruff, Julie M Behr, John D Chodera & Nicholas M Levinson

  • Posted in Nat Chem Biol, Publications
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In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins

February 6th, 2017 by Kaitlin Schaefer

Nature Chemical Biology 13, 396 (2017). doi:10.1038/nchembio.2302

Authors: Kaitlin Schaefer, Leigh M Matano, Yuan Qiao, Daniel Kahne & Suzanne Walker

  • Posted in Nat Chem Biol, Publications
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