Membrane association of monotopic phosphoglycosyl transferase underpins function

May 16th, 2018 by Leah C. Ray

Membrane association of monotopic phosphoglycosyl transferase underpins function

Membrane association of monotopic phosphoglycosyl transferase underpins function, Published online: 16 May 2018; doi:10.1038/s41589-018-0054-z

The structure of a monotopic polyprenol phosphate phosphoglycosyl transferase, PglC, reveals how it interacts with the bacterial membrane and coordinates a reaction between membrane-embedded and soluble substrates during glycoconjugate assembly.
  • Posted in Nat Chem Biol, Publications
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Electron handoff

May 16th, 2018 by Caitlin Deane

Electron handoff

Electron handoff, Published online: 16 May 2018; doi:10.1038/s41589-018-0073-9

Electron handoff

Buffering transition

May 16th, 2018 by Yiyun Song

Buffering transition

Buffering transition, Published online: 16 May 2018; doi:10.1038/s41589-018-0076-6

Buffering transition

Tracking tRNA packages

May 16th, 2018 by Achillefs N. Kapanidis

Tracking tRNA packages

Tracking tRNA packages, Published online: 16 May 2018; doi:10.1038/s41589-018-0066-8

Fast, single-molecule tracking microscopy monitors transitions between mobile and ribosome-bound fluorescent tRNAs to achieve nucleotide-resolution measurements of translation rates in living cells.

Functional phosphorylation

May 16th, 2018 by Mirella Bucci

Functional phosphorylation

Functional phosphorylation, Published online: 16 May 2018; doi:10.1038/s41589-018-0075-7

Functional phosphorylation

Identification of a <i>S. aureus</i> virulence factor by activity-based protein profiling (ABPP)

May 16th, 2018 by Christian S. Lentz

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP)

Identification of a <i>S. aureus</i> virulence factor by activity-based protein profiling (ABPP), Published online: 16 May 2018; doi:10.1038/s41589-018-0060-1

ABP profiling identifies uncharacterized S. aureus serine hydrolases, including the surface-localized FphB, which processes lipid ester substrates and is required for infection in vivo. An FphB inhibitor reduces in vivo bacterial load.
  • Posted in Nat Chem Biol, Publications
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Next-generation biocontainment systems for engineered organisms

May 16th, 2018 by Jeong Wook Lee

Next-generation biocontainment systems for engineered organisms

Next-generation biocontainment systems for engineered organisms, Published online: 16 May 2018; doi:10.1038/s41589-018-0056-x

Synthetic biology offers innovative approaches for engineering biological systems, but also supports the development of biocontainment strategies that ensure the safe application of genetically modified organisms.

tRNA tracking for direct measurements of protein synthesis kinetics in live cells

May 16th, 2018 by Ivan L. Volkov

tRNA tracking for direct measurements of protein synthesis kinetics in live cells

tRNA tracking for direct measurements of protein synthesis kinetics in live cells, Published online: 16 May 2018; doi:10.1038/s41589-018-0063-y

Combination of single-molecule tracking experiments and machine-learning approaches to monitor diffusional state transitions between ribosome-bound and free tRNAs allows codon resolution measurements of translation kinetics.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Drug-Inducible Control of Lethality Genes: A Low Background Destabilizing Domain Architecture Applied to the Gal4-UAS System in <italic toggle=”yes”>Drosophila</italic>

May 14th, 2018 by Manjunatha Kogenaru, Mark Isalan

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00302
  • Posted in ACS Synthetic Biology, Publications
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[ASAP] A Dynamic Model of Resource Allocation in Response to the Presence of a Synthetic Construct

May 9th, 2018 by Axel Nyström, Antonis Papachristodoulou, Andrew Angel

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00015