Erratum: A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation

September 19th, 2017 by Kai Papenfort

Nature Chemical Biology 13, 1137 (2017). doi:10.1038/nchembio1017-1137a

Author: Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost & Bonnie L Bassler

  • Posted in Nat Chem Biol, Publications
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Biosynthesis: SAM cycles up for colibactin

September 19th, 2017 by Steven G Van Lanen

Nature Chemical Biology 13, 1059 (2017). doi:10.1038/nchembio.2479

Author: Steven G Van Lanen

The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.

Genome mining: Digging the tunnel for chemical space

September 19th, 2017 by Ha An Nguyen

Nature Chemical Biology 13, 1061 (2017). doi:10.1038/nchembio.2480

Authors: Ha An Nguyen & Christine M Dunham

Genome mining reveals a new ribosomally synthesized and post-translationally modified peptide (RiPP) from Klebsiella pneumoniae. This new antibiotic inhibits bacterial ribosomes by obstructing the peptide exit tunnel, and its modular nature presents a unique opportunity for future engineering of antibacterial drugs.

Target class drug discovery

September 19th, 2017 by Kimberly D Barnash

Nature Chemical Biology 13, 1053 (2017). doi:10.1038/nchembio.2473

Authors: Kimberly D Barnash, Lindsey I James & Stephen V Frye

Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complimentary approach that has higher quality outcomes in early discovery efforts.

Developmental signaling: Peaking early

September 19th, 2017 by Grant Miura

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2484

Author: Grant Miura

Bioorthogonal chemistry: Click on, click off

September 19th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2482

Author: Caitlin Deane

Protein engineering: Expanding splicing versatility

September 19th, 2017 by Karin Kuehnel

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2485

Author: Karin Kuehnel

Chemical methods: DREADDs see no CNO

September 19th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2483

Author: Mirella Bucci

Detecting Activity at Different Length Scales: From Subdiffraction to Whole-Animal Activity

September 15th, 2017 by Tsz-Leung To and Xiaokun Shu

TOC Graphic

DOI: 10.1021/acs.biochem.7b00788

A New Nucleoside Antibiotic Chokes Bacterial RNA Polymerase

September 8th, 2017 by Eric P. Trautman and Jason M. Crawford

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DOI: 10.1021/acs.biochem.7b00680