The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

January 23rd, 2017 by Kenneth D Bromberg

Nature Chemical Biology 13, 317 (2017). doi:10.1038/nchembio.2282

Authors: Kenneth D Bromberg, Taylor R H Mitchell, Anup K Upadhyay, Clarissa G Jakob, Manisha A Jhala, Kenneth M Comess, Loren M Lasko, Conglei Li, Creighton T Tuzon, Yujia Dai, Fengling Li, Mohammad S Eram, Alexander Nuber, Niru B Soni, Vlasios Manaves, Mikkel A Algire, Ramzi F Sweis, Maricel Torrent, Gunnar Schotta, Chaohong Sun, Michael R Michaelides, Alex R Shoemaker, Cheryl H Arrowsmith, Peter J Brown, Vijayaratnam Santhakumar, Alberto Martin, Judd C Rice, Gary G Chiang, Masoud Vedadi, Dalia Barsyte-Lovejoy & William N Pappano

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Redox regulation: Taking AKTion on HNEs

January 23rd, 2017 by Eranthie Weerapana

Nature Chemical Biology 13, 244 (2017). doi:10.1038/nchembio.2311

Author: Eranthie Weerapana

Differential redox regulation of kinase isoforms serves to provide intricate control of cellular signaling events. In a new study, a single isoform of Akt, Akt3, is shown to be preferentially modified by lipid-derived electrophiles to modulate downstream signaling events in mammalian cells and zebrafish.

The pharmacological regulation of cellular mitophagy

January 19th, 2017 by Nikolaos D Georgakopoulos

Nature Chemical Biology 13, 136 (2017). doi:10.1038/nchembio.2287

Authors: Nikolaos D Georgakopoulos, Geoff Wells & Michelangelo Campanella

RNA structure: Untying Zika’s knots

January 19th, 2017 by Terry L. Sheppard

Nature Chemical Biology 13, 129 (2017). doi:10.1038/nchembio.2294

Author: Terry L. Sheppard

Target engagement: Shining a light

January 19th, 2017 by Kilian V M Huber

Nature Chemical Biology 13, 133 (2017). doi:10.1038/nchembio.2295

Author: Kilian V M Huber

The ability to measure the binding of a compound to its intended target in live cells or tissue is a critical parameter for drug discovery. A new method using polarized light microscopy adds to the current toolbox by enabling monitoring of target engagement in vitro and in vivo at single-cell resolution.

Pancreatic development: Changing identity

January 19th, 2017 by Grant Miura

Nature Chemical Biology 13, 129 (2017). doi:10.1038/nchembio.2293

Author: Grant Miura

Host-Pathogen interactions: Nucleotide circles of life and death

January 19th, 2017 by Lingyin Li

Nature Chemical Biology 13, 130 (2017). doi:10.1038/nchembio.2289

Author: Lingyin Li

A phosphodiesterase, CdnP, from Mycobacterium tuberculosis (M. tb.) helps the pathogen evade immune detection by degrading the second messenger cyclic di-AMP that alerts the host to its presence. Genetic knockout of CdnP dampens the virulence of the pathogen, suggesting that CdnP inhibitors are potential anti–M. tb. therapeutics.

Biosynthesis: Terrifically tailored peptides

January 19th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 129 (2017). doi:10.1038/nchembio.2292

Author: Caitlin Deane

Nitrogenase: A fuel-producing microbe

January 19th, 2017 by Holger Dobbek

Nature Chemical Biology 13, 134 (2017). doi:10.1038/nchembio.2288

Author: Holger Dobbek

Nitrogenase has the canonical ability to reduce N2 to NH3, but under certain conditions, either in vitro or in vivo, it has the additional capability to convert CO2 to CO and CO to light hydrocarbons.

RNA modification: Reading Sex-lethal

January 19th, 2017 by Grant Miura

Nature Chemical Biology 13, 129 (2017). doi:10.1038/nchembio.2291

Author: Grant Miura