Evolution of a split RNA polymerase as a versatile biosensor platform

February 13th, 2017 by Jinyue Pu

Nature Chemical Biology 13, 432 (2017). doi:10.1038/nchembio.2299

Authors: Jinyue Pu, Julia Zinkus-Boltz & Bryan C Dickinson

  • Posted in Nat Chem Biol, Publications
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An orthogonalized platform for genetic code expansion in both bacteria and eukaryotes

February 13th, 2017 by James S Italia

Nature Chemical Biology 13, 446 (2017). doi:10.1038/nchembio.2312

Authors: James S Italia, Partha Sarathi Addy, Chester J J Wrobel, Lisa A Crawford, Marc J Lajoie, Yunan Zheng & Abhishek Chatterjee

  • Posted in Nat Chem Biol, Publications
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AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons

February 13th, 2017 by Kirill Gorshkov

Nature Chemical Biology 13, 425 (2017). doi:10.1038/nchembio.2298

Authors: Kirill Gorshkov, Sohum Mehta, Santosh Ramamurthy, Gabriele V Ronnett, Feng-Quan Zhou & Jin Zhang

  • Posted in Nat Chem Biol, Publications
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Selective in vivo metabolic cell-labeling-mediated cancer targeting

February 13th, 2017 by Hua Wang

Nature Chemical Biology 13, 415 (2017). doi:10.1038/nchembio.2297

Authors: Hua Wang, Ruibo Wang, Kaimin Cai, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou, Qian Yin, Li Tang, Iwona T Dobrucki, Lawrence W Dobrucki, Eric J Chaney, Stephen A Boppart, Timothy M Fan, Stéphane Lezmi, Xuesi Chen, Lichen Yin & Jianjun Cheng

CipA and CipB as Scaffolds To Organize Proteins into Crystalline Inclusions

February 10th, 2017 by Yang Wang, Ralf Heermann and Kirsten Jung

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.6b00323

Structure and specificity of a permissive bacterial C-prenyltransferase

February 6th, 2017 by Sherif I Elshahawi

Nature Chemical Biology 13, 366 (2017). doi:10.1038/nchembio.2285

Authors: Sherif I Elshahawi, Hongnan Cao, Khaled A Shaaban, Larissa V Ponomareva, Thangaiah Subramanian, Mark L Farman, H Peter Spielmann, George N Phillips, Jon S Thorson & Shanteri Singh

This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.

  • Posted in Nat Chem Biol, Publications
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A tight tunable range for Ni(II) sensing and buffering in cells

February 6th, 2017 by Andrew W Foster

Nature Chemical Biology 13, 409 (2017). doi:10.1038/nchembio.2310

Authors: Andrew W Foster, Rafael Pernil, Carl J Patterson, Andrew J P Scott, Lars-Olof Pålsson, Robert Pal, Ian Cummins, Peter T Chivers, Ehmke Pohl & Nigel J Robinson

A water-mediated allosteric network governs activation of Aurora kinase A

February 6th, 2017 by Soreen Cyphers

Nature Chemical Biology 13, 402 (2017). doi:10.1038/nchembio.2296

Authors: Soreen Cyphers, Emily F Ruff, Julie M Behr, John D Chodera & Nicholas M Levinson

  • Posted in Nat Chem Biol, Publications
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In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins

February 6th, 2017 by Kaitlin Schaefer

Nature Chemical Biology 13, 396 (2017). doi:10.1038/nchembio.2302

Authors: Kaitlin Schaefer, Leigh M Matano, Yuan Qiao, Daniel Kahne & Suzanne Walker

  • Posted in Nat Chem Biol, Publications
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Call for Papers: 254th ACS Meeting August 20-24, 2017 in Washington DC

February 2nd, 2017 by pthomas2

Abstract deadline Monday March 20, 2017. In addition to poster sessions, there will be oral sessions for contributed papers from Graduate students and postdocs, Early Career Investigators and Mid-Career Investigators. Speakers for these symposia will be selected from the submitted abstracts. If your abstract is not chosen for an oral presentation, it will be moved to a poster session. Click here to submit abstract.

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