Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability

June 12th, 2017 by Stefanie Kellner

Nature Chemical Biology 13, 888 (2017). doi:10.1038/nchembio.2407

Authors: Stefanie Kellner, Michael S DeMott, Ching Pin Cheng, Brandon S Russell, Bo Cao, Delin You & Peter C Dedon

  • Posted in Nat Chem Biol, Publications
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Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

June 5th, 2017 by Niels S van der Velden

Nature Chemical Biology 13, 833 (2017). doi:10.1038/nchembio.2393

Authors: Niels S van der Velden, Noemi Kälin, Maximilian J Helf, Jörn Piel, Michael F Freeman & Markus Künzler

Peptide backbone N-methylation, as seen in cyclosporin A, has been considered to be exclusive to nonribosomal peptides. We have identified the first post-translationally modified peptide or protein harboring internal α-N-methylations through discovery of the genetic locus for the omphalotins, cyclic N-methylated peptides produced by the fungus Omphalotus olearius. We show that iterative autocatalytic activity of an N-methyltransferase fused to its peptide substrate is the signature of a new family of ribosomally encoded metabolites.

  • Posted in Nat Chem Biol, Publications
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Parallel evolution of non-homologous isofunctional enzymes in methionine biosynthesis

June 5th, 2017 by Karine Bastard

Nature Chemical Biology 13, 858 (2017). doi:10.1038/nchembio.2397

Authors: Karine Bastard, Alain Perret, Aline Mariage, Thomas Bessonnet, Agnès Pinet-Turpault, Jean-Louis Petit, Ekaterina Darii, Pascal Bazire, Carine Vergne-Vaxelaire, Clémence Brewee, Adrien Debard, Virginie Pellouin, Marielle Besnard-Gonnet, François Artiguenave, Claudine Médigue, David Vallenet, Antoine Danchin, Anne Zaparucha, Jean Weissenbach, Marcel Salanoubat & Véronique de Berardinis

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Activity-based probes for functional interrogation of retaining β-glucuronidases

June 5th, 2017 by Liang Wu

Nature Chemical Biology 13, 867 (2017). doi:10.1038/nchembio.2395

Authors: Liang Wu, Jianbing Jiang, Yi Jin, Wouter W Kallemeijn, Chi-Lin Kuo, Marta Artola, Wei Dai, Cas van Elk, Marco van Eijk, Gijsbert A van der Marel, Jeroen D C Codée, Bogdan I Florea, Johannes M F G Aerts, Herman S Overkleeft & Gideon J Davies

  • Posted in Nat Chem Biol, Publications
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Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase

June 5th, 2017 by Daniel C Scott

Nature Chemical Biology 13, 850 (2017). doi:10.1038/nchembio.2386

Authors: Daniel C Scott, Jared T Hammill, Jaeki Min, David Y Rhee, Michele Connelly, Vladislav O Sviderskiy, Deepak Bhasin, Yizhe Chen, Su-Sien Ong, Sergio C Chai, Asli N Goktug, Guochang Huang, Julie K Monda, Jonathan Low, Ho Shin Kim, Joao A Paulo, Joe R Cannon, Anang A Shelat, Taosheng Chen, Ian R Kelsall, Arno F Alpi, Vishwajeeth Pagala, Xusheng Wang, Junmin Peng, Bhuvanesh Singh, J Wade Harper, Brenda A Schulman & R Kip Guy

  • Posted in Nat Chem Biol, Publications
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Remote Perturbations in Tertiary Contacts Trigger Ligation of Lysine to the Heme Iron in Cytochrome c

May 31st, 2017 by Jie Gu, Dong-Woo Shin and Ekaterina V. Pletneva

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.6b01187

Call for Nominations for 2017-2018 ACS Division of Biological Chemistry Awards

May 30th, 2017 by pthomas2

Nominations are requested for the Eli Lilly Award in Biological Chemistry, the Pfizer Award in Enzyme Chemistry, and the Repligen Award in Chemistry of Biological Processes in addition to the Gordon Hammes Biochemistry Lectureship, the ACS Chemical Biology Lectureship and the Murray Goodman Memorial Prize, please visit the Nominations page for more information.

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Structural and functional characterization of the hydrogenase-maturation HydF protein

May 29th, 2017 by Giorgio Caserta

Nature Chemical Biology 13, 779 (2017). doi:10.1038/nchembio.2385

Authors: Giorgio Caserta, Ludovic Pecqueur, Agnieszka Adamska-Venkatesh, Cecilia Papini, Souvik Roy, Vincent Artero, Mohamed Atta, Edward Reijerse, Wolfgang Lubitz & Marc Fontecave

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Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams

May 29th, 2017 by Yuan Qiao

Nature Chemical Biology 13, 793 (2017). doi:10.1038/nchembio.2388

Authors: Yuan Qiao, Veerasak Srisuknimit, Frederick Rubino, Kaitlin Schaefer, Natividad Ruiz, Suzanne Walker & Daniel Kahne

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Structural basis for high-affinity fluorophore binding and activation by RNA Mango

May 29th, 2017 by Robert J Trachman

Nature Chemical Biology 13, 807 (2017). doi:10.1038/nchembio.2392

Authors: Robert J Trachman, Natalia A Demeshkina, Matthew W L Lau, Shanker Shyam S Panchapakesan, Sunny C Y Jeng, Peter J Unrau & Adrian R Ferré-D'Amaré

  • Posted in Nat Chem Biol, Publications
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