Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

November 28th, 2016 by Hans Michael Maric

Nature Chemical Biology 13, 153 (2017). doi:10.1038/nchembio.2246

Authors: Hans Michael Maric, Torben Johann Hausrat, Franziska Neubert, Nils Ole Dalby, Sören Doose, Markus Sauer, Matthias Kneussel & Kristian Strømgaard

  • Posted in Nat Chem Biol, Publications
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Activation and reduction of carbon dioxide by nitrogenase iron proteins

November 28th, 2016 by Johannes G Rebelein

Nature Chemical Biology 13, 147 (2017). doi:10.1038/nchembio.2245

Authors: Johannes G Rebelein, Martin T Stiebritz, Chi Chung Lee & Yilin Hu

The iron (Fe) proteins of molybdenum (Mo) and vanadium (V) nitrogenases mimic carbon monoxide (CO) dehydrogenase in catalyzing the interconversion between CO2 and CO under ambient conditions. Catalytic reduction of CO2 to CO is achieved in vitro and in vivo upon redox changes of the Fe-protein-associated [Fe4S4] clusters. These observations establish the Fe protein as a model for investigation of CO2 activation while suggesting its biotechnological adaptability for recycling the greenhouse gas into useful products.

  • Posted in Nat Chem Biol, Publications
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Ubiquitin utilizes an acidic surface patch to alter chromatin structure

November 21st, 2016 by Galia T Debelouchina

Nature Chemical Biology 13, 105 (2017). doi:10.1038/nchembio.2235

Authors: Galia T Debelouchina, Karola Gerecht & Tom W Muir

  • Posted in Nat Chem Biol, Publications
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A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics

November 21st, 2016 by John C Rose

Nature Chemical Biology 13, 119 (2017). doi:10.1038/nchembio.2244

Authors: John C Rose, Po-Ssu Huang, Nathan D Camp, Jordan Ye, Andrew M Leidal, Inna Goreshnik, Bridget M Trevillian, Miles S Dickinson, Daniel Cunningham-Bryant, Jayanta Debnath, David Baker, Alejandro Wolf-Yadlin & Dustin J Maly

  • Posted in Nat Chem Biol, Publications
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The RNA helicase Mtr4p is a duplex-sensing translocase

November 21st, 2016 by Eric M Patrick

Nature Chemical Biology 13, 99 (2017). doi:10.1038/nchembio.2234

Authors: Eric M Patrick, Sukanya Srinivasan, Eckhard Jankowsky & Matthew J Comstock

Full antagonism of the estrogen receptor without a prototypical ligand side chain

November 21st, 2016 by Sathish Srinivasan

Nature Chemical Biology 13, 111 (2017). doi:10.1038/nchembio.2236

Authors: Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Venkatasubramanian Dharmarajan, Devrishi Goswami, Irida Kastrati, Scott Novick, Jason Nowak, Valerie Cavett, Hai-Bing Zhou, Nittaya Boonmuen, Yuechao Zhao, Jian Min, Jonna Frasor, Benita S Katzenellenbogen, Patrick R Griffin, John A Katzenellenbogen & Kendall W Nettles

  • Posted in Nat Chem Biol, Publications
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RNA structure: Know when to fold ’em

November 15th, 2016 by Grant Miura

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2255

Author: Grant Miura

Drug discovery: Doubling down on BET inhibition

November 15th, 2016 by Dafydd Owen

Nature Chemical Biology 12, 991 (2016). doi:10.1038/nchembio.2242

Author: Dafydd Owen

Through simultaneous binding to more than one site in a single protein, multivalent small molecules can achieve huge increases in potency. This 'avidity effect' has been demonstrated in BET bromodomain-containing proteins with bivalent probes that represent some of the most potent BET inhibitors to date.

Epigenomics: Massive ATAC

November 15th, 2016 by Joshua M. Finkelstein

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2257

Author: Joshua M. Finkelstein

Protein synthesis: Breaking down the NSA1

November 15th, 2016 by Grant Miura

Nature Chemical Biology 12, 989 (2016). doi:10.1038/nchembio.2258

Author: Grant Miura