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October 13th, 2017 by Jillian L. Dempsey and Matthew R. Hartings

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Biochemistry
DOI: 10.1021/acs.biochem.7b00950

Fluorotryptophan Incorporation Modulates the Structure and Stability of Transthyretin in a Site-Specific Manner

September 28th, 2017 by Xun Sun, H. Jane Dyson and Peter E. Wright

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Biochemistry
DOI: 10.1021/acs.biochem.7b00815

Transfer Hydrogenation Catalyzed by Organometallic Complexes Using NADH as a Reductant in a Biochemical Context

September 27th, 2017 by Yasunori Okamoto and Thomas R. Ward

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Biochemistry
DOI: 10.1021/acs.biochem.7b00809

Cation−π Lights Up “Halo”

September 20th, 2017 by Jianmin Gao

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Biochemistry
DOI: 10.1021/acs.biochem.7b00702

Erratum: A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation

September 19th, 2017 by Kai Papenfort

Nature Chemical Biology 13, 1137 (2017). doi:10.1038/nchembio1017-1137b

Author: Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost & Bonnie L Bassler

  • Posted in Nat Chem Biol, Publications
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Corrigendum: Parallel evolution of non-homologous isofunctional enzymes in methionine biosynthesis

September 19th, 2017 by Karine Bastard

Nature Chemical Biology 13, 1137 (2017). doi:10.1038/nchembio1017-1137c

Author: Karine Bastard, Alain Perret, Aline Mariage, Thomas Bessonnet, Agnès Pinet-Turpault, Jean-Louis Petit, Ekaterina Darii, Pascal Bazire, Carine Vergne-Vaxelaire, Clémence Brewee, Adrien Debard, Virginie Pellouin, Marielle Besnard-Gonnet, François Artiguenave, Claudine Médigue, David Vallenet, Antoine Danchin, Anne Zaparucha, Jean Weissenbach, Marcel Salanoubat & Véronique de Berardinis

  • Posted in Nat Chem Biol, Publications
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Erratum: A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation

September 19th, 2017 by Kai Papenfort

Nature Chemical Biology 13, 1137 (2017). doi:10.1038/nchembio1017-1137a

Author: Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost & Bonnie L Bassler

  • Posted in Nat Chem Biol, Publications
  • Comments Off on Erratum: A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation

Biosynthesis: SAM cycles up for colibactin

September 19th, 2017 by Steven G Van Lanen

Nature Chemical Biology 13, 1059 (2017). doi:10.1038/nchembio.2479

Author: Steven G Van Lanen

The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.

Genome mining: Digging the tunnel for chemical space

September 19th, 2017 by Ha An Nguyen

Nature Chemical Biology 13, 1061 (2017). doi:10.1038/nchembio.2480

Authors: Ha An Nguyen & Christine M Dunham

Genome mining reveals a new ribosomally synthesized and post-translationally modified peptide (RiPP) from Klebsiella pneumoniae. This new antibiotic inhibits bacterial ribosomes by obstructing the peptide exit tunnel, and its modular nature presents a unique opportunity for future engineering of antibacterial drugs.

Target class drug discovery

September 19th, 2017 by Kimberly D Barnash

Nature Chemical Biology 13, 1053 (2017). doi:10.1038/nchembio.2473

Authors: Kimberly D Barnash, Lindsey I James & Stephen V Frye

Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complimentary approach that has higher quality outcomes in early discovery efforts.