Tuning the Flexibility of Glycine-Serine Linkers To Allow Rational Design of Multidomain Proteins

December 7th, 2017 by Martijn van Rosmalen, Mike Krom and Maarten Merkx

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Biochemistry
DOI: 10.1021/acs.biochem.7b00902

Novel Biology and Druggable Targets via Chemoproteomics

December 7th, 2017 by Alan Saghatelian

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Biochemistry
DOI: 10.1021/acs.biochem.7b01167

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

December 4th, 2017 by Gerald Gavory

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors, Published online: 04 December 2017; doi:10.1038/nchembio.2528

A selective inhibitor of the deubiquitinase USP7 binds an allosteric site to inhibit its MDM2-stabilizing activity, resulting in stabilization of p53 and p21, which confers hypersensitivity to cancer cells for killing by the compound.
  • Posted in Nat Chem Biol, Publications
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Human antibody-based chemically induced dimerizers for cell therapeutic applications

December 4th, 2017 by Zachary B Hill

Human antibody-based chemically induced dimerizers for cell therapeutic applications

Human antibody-based chemically induced dimerizers for cell therapeutic applications, Published online: 04 December 2017; doi:10.1038/nchembio.2529

Selections with a phage-displayed antibody library against an existing protein–small-molecule complex enabled the generation of antibody-based chemically induced dimerizers (AbCIDs) with the properties necessary for use in regulating cell therapies.
  • Posted in Nat Chem Biol, Publications
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Fluorescent Probes of DNA Repair

November 30th, 2017 by David L. Wilson and Eric T. Kool

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00919

Incorporation of β-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2

November 30th, 2017 by Myung-Ryul Lee, Namrata Raman, Samuel H. Gellman, David M. Lynn and Sean P. Palecek

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00843
  • Posted in ACS Chemical Biology, Publications
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Biochemical Basis of Vosevi, a New Treatment for Hepatitis C

November 29th, 2017 by Ronald Besandre and Hung-wen Liu

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Biochemistry
DOI: 10.1021/acs.biochem.7b01157

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing

November 29th, 2017 by Roger L. Williams and Madhanagopal Anandapadamanaban

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Biochemistry
DOI: 10.1021/acs.biochem.7b01120

Cell-Free and In Vivo Characterization of Lux, Las, and Rpa Quorum Activation Systems in E. coli

November 28th, 2017 by Andrew D. Halleran and Richard M. Murray

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00376

5-Formylcytosine to cytosine conversion by C–C bond cleavage <i>in vivo</i>

November 27th, 2017 by Katharina Iwan

5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo

5-Formylcytosine to cytosine conversion by C–C bond cleavage <i>in vivo</i>, Published online: 27 November 2017; doi:10.1038/nchembio.2531

Direct conversion of 5-fdC into dC by C–C bond breakage is revealed by metabolic tracing studies through incorporation of synthetic stable isotope- and (R)-2′-fluorine-labeled dC and fdC derivatives into the genome of cultured mammalian cells.
  • Posted in Nat Chem Biol, Publications
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