Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters

April 17th, 2017 by Menglu Wang

Nature Chemical Biology 13, 660 (2017). doi:10.1038/nchembio.2361

Authors: Menglu Wang, Lucile Moynié, Peter J Harrison, Van Kelly, Andrew Piper, James H Naismith & Dominic J Campopiano

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Deep Sequencing Analysis of Aptazyme Variants Based on a Pistol Ribozyme

April 14th, 2017 by Shungo Kobori, Kei Takahashi and Yohei Yokobayashi

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00057

The chemical basis for electrical signaling

April 13th, 2017 by William A Catterall

Nature Chemical Biology 13, 455 (2017). doi:10.1038/nchembio.2353

Authors: William A Catterall, Goragot Wisedchaisri & Ning Zheng

Anti-Bacterials: Out-SMARting drug resistance

April 13th, 2017 by Alison Farrell

Nature Chemical Biology 13, 451 (2017). doi:10.1038/nchembio.2368

Author: Alison Farrell

Targeted protein degradation: You can glue it too!

April 13th, 2017 by Michal J Walczak

Nature Chemical Biology 13, 452 (2017). doi:10.1038/nchembio.2355

Authors: Michal J Walczak, Georg Petzold & Nicolas H Thomä

Proteolysis-targeting chimera (PROTACs) are synthetic molecules that recruit neo-substrate proteins to a ubiquitin ligase for ubiquitination and subsequent degradation. Structural insight into the VHL–MZ1–BRD4 complex reveals how the rationally designed MZ1–PROTAC molecule mediates degradation of an unnatural protein substrate.

Intrinsic Disorder: Fuzzy fast feedback

April 13th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 451 (2017). doi:10.1038/nchembio.2367

Author: Mirella Bucci

Microbiology: A new language for small talk

April 13th, 2017 by Yi-Ming Shi

Nature Chemical Biology 13, 453 (2017). doi:10.1038/nchembio.2362

Authors: Yi-Ming Shi & Helge B Bode

A new signal–receptor pair involved in regulating biofilm formation and virulence was detected in Vibrio cholerae. Both the signal and the transcription factor belong to common classes of natural products and receptor proteins, suggesting widespread importance of related systems in nature.

Bacterial Membranes: Tear down this wall

April 13th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 451 (2017). doi:10.1038/nchembio.2366

Author: Caitlin Deane

Optogenetics: Lighting up kinases

April 13th, 2017 by Grant Miura

Nature Chemical Biology 13, 451 (2017). doi:10.1038/nchembio.2365

Author: Grant Miura

Mechanistic insights into energy conservation by flavin-based electron bifurcation

April 10th, 2017 by Carolyn E Lubner

Nature Chemical Biology 13, 655 (2017). doi:10.1038/nchembio.2348

Authors: Carolyn E Lubner, David P Jennings, David W Mulder, Gerrit J Schut, Oleg A Zadvornyy, John P Hoben, Monika Tokmina-Lukaszewska, Luke Berry, Diep M Nguyen, Gina L Lipscomb, Brian Bothner, Anne K Jones, Anne-Frances Miller, Paul W King, Michael W W Adams & John W Peters

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