RNA Splicing: Making the cut

January 16th, 2018 by Stéphane Larochelle

RNA Splicing: Making the cut

RNA Splicing: Making the cut, Published online: 16 January 2018; doi:10.1038/nchembio.2564

RNA Splicing: Making the cut

Plant hormones: Metabolic end run to jasmonate

January 16th, 2018 by Gregg A Howe

Plant hormones: Metabolic end run to jasmonate

Plant hormones: Metabolic end run to jasmonate, Published online: 16 January 2018; doi:10.1038/nchembio.2553

The lipid-derived hormone jasmonate promotes durable resistance of plants to a myriad of herbivores and pathogens. New evidence reveals an alternative pathway for the terminal steps of jasmonate biosynthesis and further advances our understanding of bioactive oxylipins in the plant kingdom.

Cell biology: Eaten up from the inside

January 16th, 2018 by Karin Kuehnel

Cell biology: Eaten up from the inside

Cell biology: Eaten up from the inside, Published online: 16 January 2018; doi:10.1038/nchembio.2563

Cell biology: Eaten up from the inside

Toward an orthogonal central dogma

January 16th, 2018 by Chang C Liu

Toward an orthogonal central dogma

Toward an orthogonal central dogma, Published online: 16 January 2018; doi:10.1038/nchembio.2554

The central dogma processes of DNA replication, transcription, and translation are responsible for the maintenance and expression of every gene in an organism. An orthogonal central dogma may insulate genetic programs from host regulation and allow expansion of the roles of these processes within the cell.

Identifying Novel Enhancer Elements with CRISPR-Based Screens

January 10th, 2018 by Jason C. Klein, Wei Chen, Molly Gasperini and Jay Shendure

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00778

Metabolic Feedback Circuits Provide Rapid Control of Metabolite Dynamics

January 8th, 2018 by Di Liu and Fuzhong Zhang

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00342

Na<sup>+</sup>-mimicking ligands stabilize the inactive state of leukotriene B<sub>4</sub> receptor BLT1

January 8th, 2018 by Tetsuya Hori

Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1

Na<sup>+</sup>-mimicking ligands stabilize the inactive state of leukotriene B<sub>4</sub> receptor BLT1, Published online: 08 January 2018; doi:10.1038/nchembio.2547

A structure of leukotriene B4 receptor BLT1 bound with a benzamidine-containing compound, BIIL260, reveals an inverse-agonist mechanism involving ligand binding in the sodium ion-centered water cluster adjacent to the conserved orthosteric site of class A GPCRs.
  • Posted in Nat Chem Biol, Publications
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Employing a biochemical protecting group for a sustainable indigo dyeing strategy

January 8th, 2018 by Tammy M Hsu

Employing a biochemical protecting group for a sustainable indigo dyeing strategy

Employing a biochemical protecting group for a sustainable indigo dyeing strategy, Published online: 08 January 2018; doi:10.1038/nchembio.2552

An environmentally friendly approach to indigo production is facilitated by the characterization of a plant indoxyl glucosyltransferase, which converts the unstable indoxyl precursor into indican by addition of a glucose protecting group.
  • Posted in Nat Chem Biol, Publications
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Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases

January 8th, 2018 by Matthew Jenner

Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases

Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases, Published online: 08 January 2018; doi:10.1038/nchembio.2549

A combination of biochemical and structural techniques allows the characterization of a novel docking domain in polyketide synthases, which is structurally disordered and facilitates association of subunits at ketosynthase–dehydratase junctions.
  • Posted in Nat Chem Biol, Publications
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Next-Generation DNA-Functionalized Quantum Dots as Biological Sensors

January 4th, 2018 by Ganglin Wang, Zhi Li and Nan Ma

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00887