Antibacterials: PUMmeling RNAP

July 18th, 2017 by Terry L. Sheppard

Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2446

Author: Terry L. Sheppard

Erratum: The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

July 18th, 2017 by Yupeng He

Nature Chemical Biology 13, 922 (2017). doi:10.1038/nchembio0817-922b

Author: Yupeng He, Sujatha Selvaraju, Michael L Curtin, Clarissa G Jakob, Haizhong Zhu, Kenneth M Comess, Bailin Shaw, Juliana The, Evelyne Lima-Fernandes, Magdalena M Szewczyk, Dong Cheng, Kelly L Klinge, Huan-Qiu Li, Marina Pliushchev, Mikkel A Algire, David Maag, Jun Guo, Justin Dietrich, Sanjay C Panchal, Andrew M Petros, Ramzi F Sweis, Maricel Torrent, Lance J Bigelow, Guillermo Senisterra, Fengling Li, Steven Kennedy, Qin Wu, Donald J Osterling, David J Lindley, Wenqing Gao, Scott Galasinski, Dalia Barsyte-Lovejoy, Masoud Vedadi, Fritz G Buchanan, Cheryl H Arrowsmith, Gary G Chiang, Chaohong Sun & William N Pappano

  • Posted in Nat Chem Biol, Publications
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Enzymology: Tracking off-targets

July 18th, 2017 by Alison Farrell

Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2445

Author: Alison Farrell

Redox regulation: Scaffolding H2O2 signaling

July 18th, 2017 by Hadley D Sikes

Nature Chemical Biology 13, 818 (2017). doi:10.1038/nchembio.2432

Author: Hadley D Sikes

Peroxidases, rather than simply reducing H2O2 to water, also convey oxidation signals to proteins such as transcription factors. A new study reveals how a scaffold protein enables formation of a mixed disulfide between the peroxidase and a transcription factor.

Neurodegenerative disease: Not stuck on repeat

July 18th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 817 (2017). doi:10.1038/nchembio.2444

Author: Mirella Bucci

Biosynthesis: Methylating mushrooms

July 18th, 2017 by Albert A Bowers

Nature Chemical Biology 13, 821 (2017). doi:10.1038/nchembio.2437

Author: Albert A Bowers

The genome of the poisonous mushroom Omphalotus olearius provides a potent new biocatalytic strategy for installing backbone N-methyl amides on ribosomally synthesized peptides. This discovery could yield new biotechnologies for drug development from peptide macrocycles.

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

July 17th, 2017 by Deepankar Gahloth

Nature Chemical Biology 13, 975 (2017). doi:10.1038/nchembio.2434

Authors: Deepankar Gahloth, Mark S Dunstan, Daniela Quaglia, Evaldas Klumbys, Michael P Lockhart-Cairns, Andrew M Hill, Sasha R Derrington, Nigel S Scrutton, Nicholas J Turner & David Leys

  • Posted in Nat Chem Biol, Publications
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An excited state underlies gene regulation of a transcriptional riboswitch

July 17th, 2017 by Bo Zhao

Nature Chemical Biology 13, 968 (2017). doi:10.1038/nchembio.2427

Authors: Bo Zhao, Sharon L Guffy, Benfeard Williams & Qi Zhang

  • Posted in Nat Chem Biol, Publications
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Developing a Genetically Encoded, Cross-Species Biosensor for Detecting Ammonium and Regulating Biosynthesis of Cyanophycin

July 13th, 2017 by Yi Xiao, Wen Jiang and Fuzhong Zhang

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00069
  • Posted in ACS Synthetic Biology, Publications
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The structure of vanadium nitrogenase reveals an unusual bridging ligand

July 10th, 2017 by Daniel Sippel

Nature Chemical Biology 13, 956 (2017). doi:10.1038/nchembio.2428

Authors: Daniel Sippel & Oliver Einsle

  • Posted in Nat Chem Biol, Publications
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