Small-molecule pheromones and hormones controlling nematode development

May 17th, 2017 by Rebecca A Butcher

Nature Chemical Biology 13, 577 (2017). doi:10.1038/nchembio.2356

Author: Rebecca A Butcher

  • Posted in Nat Chem Biol, Publications
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Optogenetics: Switching with red and blue

May 17th, 2017 by Fuun Kawano

Nature Chemical Biology 13, 573 (2017). doi:10.1038/nchembio.2387

Authors: Fuun Kawano, Fan Shi & Masayuki Yazawa

Multiple optogenetic technologies are required to control biological activity simultaneously with different colors of light. Optimizing a near-infrared-induced heterodimerization system, which can be combined with blue-light-controlled domains, enables precise spatiotemporal control of target molecules in live mammalian cells.

Erratum: A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation

May 17th, 2017 by Kai Papenfort

Nature Chemical Biology 13, 691 (2017). doi:10.1038/nchembio0617-691a

Author: Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost & Bonnie L Bassler

  • Posted in Nat Chem Biol, Publications
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Signal Transduction: Notch catches a Jagged edge

May 17th, 2017 by Stephen C Blacklow

Nature Chemical Biology 13, 570 (2017). doi:10.1038/nchembio.2379

Author: Stephen C Blacklow

Notch signaling is an essential cell–cell communication pathway that influences numerous cell fate decisions during development. Structural and biochemical studies of a Notch–Jagged complex dramatically advance current understanding of ligand recognition, and reveal evidence of catch-bond behavior in the complex.

Plant development: Get lit on steroids

May 17th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 569 (2017). doi:10.1038/nchembio.2401

Author: Mirella Bucci

Synthetic biology: Return to sender

May 17th, 2017 by Grant Miura

Nature Chemical Biology 13, 569 (2017). doi:10.1038/nchembio.2398

Author: Grant Miura

Enzymology: Radical ring resizing

May 17th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 569 (2017). doi:10.1038/nchembio.2399

Author: Caitlin Deane

Unraveling cell-to-cell signaling networks with chemical biology

May 17th, 2017 by Zev J Gartner

Nature Chemical Biology 13, 564 (2017). doi:10.1038/nchembio.2391

Authors: Zev J Gartner, Jennifer A Prescher & Luke D Lavis

Cell-to-cell signaling networks, although poorly understood, guide tissue development, regulate tissue function and may become dysregulated in disease. Chemical biologists can develop the next generation of tools to untangle these complex and dynamic networks of interacting cells.

Infectious disease: A lethal sugar fix

May 17th, 2017 by Alison Farrell

Nature Chemical Biology 13, 569 (2017). doi:10.1038/nchembio.2400

Author: Alison Farrell

Small-molecule phenotypic screening with stem cells

May 17th, 2017 by Andrei Ursu

Nature Chemical Biology 13, 560 (2017). doi:10.1038/nchembio.2383

Authors: Andrei Ursu, Hans R Schöler & Herbert Waldmann

To fully leverage the potential of human-induced pluripotent stem cells (hiPSCs), improved and standardized reprogramming methods and large-scale collections of hiPSC lines are needed, and the stem cell community must embrace chemical biology methodology for target identification and validation.