[ASAP] Investigation of Human Neutrophil Elastase Inhibition by <italic toggle=”yes”>Staphylococcus aureus</italic> EapH1: The Key Role Played by Arginine 89

November 30th, 2018 by Timothy J. Herdendorf, Brian V. Geisbrecht

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Biochemistry
DOI: 10.1021/acs.biochem.8b01134

[ASAP] Endoplasmic Reticulum–Endosome Contact Sites: Specialized Interfaces for Orchestrating Endosomal Tubule Fission?

November 30th, 2018 by James L. Daly, Peter J. Cullen

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Biochemistry
DOI: 10.1021/acs.biochem.8b01176

<i>Escherichia</i> coli “Marionette” strains with 12 highly optimized small-molecule sensors

November 26th, 2018 by Adam J. Meyer

Escherichia coli “Marionette” strains with 12 highly optimized small-molecule sensors

<i>Escherichia</i> coli “Marionette” strains with 12 highly optimized small-molecule sensors, Published online: 26 November 2018; doi:10.1038/s41589-018-0168-3

A directed evolution approach was applied to optimize a set of 12 small-molecule-responsive biosensors, which led to the engineering of “Marionette” strains of Escherichia coli incorporating these sensors for biotechnological applications.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Discovery and Characterization of a Naturally Occurring, Turn-On Yellow Fluorescent Protein Sensor for Chloride

November 21st, 2018 by Jasmine N. Tutol, Weicheng Peng, Sheel C. Dodani

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Biochemistry
DOI: 10.1021/acs.biochem.8b00928

[ASAP] Hinge–Linker Elements in the AAA+ Protein Unfoldase ClpX Mediate Intersubunit Communication, Assembly, and Mechanical Activity

November 20th, 2018 by Tristan A. Bell, Tania A. Baker, Robert T. Sauer

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Biochemistry
DOI: 10.1021/acs.biochem.8b00907

[ASAP] Understanding and Engineering Distributed Biochemical Pathways in Microbial Communities

November 20th, 2018 by Xinyun Cao, Joshua J. Hamilton, Ophelia S. Venturelli

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Biochemistry
DOI: 10.1021/acs.biochem.8b01006

Polarized displacement by transcription activator-like effectors for regulatory circuits

November 19th, 2018 by Tina Lebar

Polarized displacement by transcription activator-like effectors for regulatory circuits

Polarized displacement by transcription activator-like effectors for regulatory circuits, Published online: 19 November 2018; doi:10.1038/s41589-018-0163-8

The observation that transcription activator-like effectors (TALES) displace TALES bound at adjacent downstream DNA enables engineered regulation of gene expression, displacement of other DNA binding proteins and construction of logic-gated systems.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Binding Affinity and Function of the Extremely Disordered Protein Complex Containing Human Linker Histone H1.0 and Its Chaperone ProTa

November 19th, 2018 by Hanqiao Feng, Bing-Rui Zhou, Yawen Bai

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Biochemistry
DOI: 10.1021/acs.biochem.8b01075

Identification of <i>Chaoborus</i> kairomone chemicals that induce defences in <i>Daphnia</i>

November 14th, 2018 by Linda C. Weiss

Identification of Chaoborus kairomone chemicals that induce defences in Daphnia

Identification of <i>Chaoborus</i> kairomone chemicals that induce defences in <i>Daphnia</i>, Published online: 14 November 2018; doi:10.1038/s41589-018-0164-7

The freshwater microcrustacean Daphnia pulex forms defensive neckteeth in response to a collection of chemical cues (the kairomone), now identified as certain fatty acids conjugated to glutamine, released during digestion by its predator Chaoborus.
  • Posted in Nat Chem Biol, Publications
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Failure to convert

November 14th, 2018 by Grant Miura

Failure to convert

Failure to convert, Published online: 14 November 2018; doi:10.1038/s41589-018-0172-7

Failure to convert