Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel

August 28th, 2017 by Mikhail Metelev

Nature Chemical Biology 13, 1129 (2017). doi:10.1038/nchembio.2462

Authors: Mikhail Metelev, Ilya A Osterman, Dmitry Ghilarov, Nelli F Khabibullina, Alexander Yakimov, Konstantin Shabalin, Irina Utkina, Dmitry Y Travin, Ekaterina S Komarova, Marina Serebryakova, Tatyana Artamonova, Mikhail Khodorkovskii, Andrey L Konevega, Petr V Sergiev, Konstantin Severinov & Yury S Polikanov

  • Posted in Nat Chem Biol, Publications
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Staphylococcus aureus CidC Is a Pyruvate:Menaquinone Oxidoreductase

August 25th, 2017 by Xinyan Zhang, Kenneth W. Bayles and Sorin Luca

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Biochemistry
DOI: 10.1021/acs.biochem.7b00570

Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae

August 24th, 2017 by Choong-Soo Yun, Takayuki Motoyama and Hiroyuki Osada

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00353

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529

August 21st, 2017 by Marie Pancera

Nature Chemical Biology 13, 1115 (2017). doi:10.1038/nchembio.2460

Authors: Marie Pancera, Yen-Ting Lai, Tatsiana Bylund, Aliaksandr Druz, Sandeep Narpala, Sijy O'Dell, Arne Schön, Robert T Bailer, Gwo-Yu Chuang, Hui Geng, Mark K Louder, Reda Rawi, Djade I Soumana, Andrés Finzi, Alon Herschhorn, Navid Madani, Joseph Sodroski, Ernesto Freire, David R Langley, John R Mascola, Adrian B McDermott & Peter D Kwong

  • Posted in Nat Chem Biol, Publications
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Metals induce transient folding and activation of the twister ribozyme

August 21st, 2017 by Subrata Panja

Nature Chemical Biology 13, 1109 (2017). doi:10.1038/nchembio.2459

Authors: Subrata Panja, Boyang Hua, Diego Zegarra, Taekjip Ha & Sarah A Woodson

  • Posted in Nat Chem Biol, Publications
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Controlling Bdellovibrio bacteriovorus Gene Expression and Predation Using Synthetic Riboswitches

August 18th, 2017 by Mohammed Dwidar and Yohei Yokobayashi

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00171

Ubiquitin-proteasome system: Rescuing EBV latency

August 18th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 923 (2017). doi:10.1038/nchembio.2466

Author: Mirella Bucci

A kinetic view of GPCR allostery and biased agonism

August 18th, 2017 by J Robert Lane

Nature Chemical Biology 13, 929 (2017). doi:10.1038/nchembio.2431

Authors: J Robert Lane, Lauren T May, Robert G Parton, Patrick M Sexton & Arthur Christopoulos

Drug development: Locking down metabolism

August 18th, 2017 by William R Bishai

Nature Chemical Biology 13, 925 (2017). doi:10.1038/nchembio.2452

Author: William R Bishai

An allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase—an enzyme that is nonessential for in vitro growth—has potent antimicrobial activity, revealing a potentially expanded target list for antimicrobials and greater chemical space for new inhibitors.

Bacterial immunity: A virtuous CRISPR cycle

August 18th, 2017 by Terry L. Sheppard

Nature Chemical Biology 13, 923 (2017). doi:10.1038/nchembio.2468

Author: Terry L. Sheppard