Biosynthesis of redox-active metabolites in response to iron deficiency in plants

March 26th, 2018 by Jakub Rajniak

Biosynthesis of redox-active metabolites in response to iron deficiency in plants

Biosynthesis of redox-active metabolites in response to iron deficiency in plants, Published online: 26 March 2018; doi:10.1038/s41589-018-0019-2

The biosynthesis and secretion of redox-active coumarins sideretin and fraxetin in Arabidopsis thaliana enables the plant to acquire iron under nutrient-limited conditions and provides a blueprint for the use of related compounds in other eudicots.
  • Posted in Nat Chem Biol, Publications
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Unfolding of a ClC chloride transporter retains memory of its evolutionary history

March 26th, 2018 by Duyoung Min

Unfolding of a ClC chloride transporter retains memory of its evolutionary history

Unfolding of a ClC chloride transporter retains memory of its evolutionary history, Published online: 26 March 2018; doi:10.1038/s41589-018-0025-4

A single-molecule forced unfolding of E. coli chloride transporter ClC-ec1 shows that the N- and C-terminal halves of the protein unfold independently, with exposed polar surfaces stabilized by membrane lipid head groups and water.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Structures of the Catalytic Domain of Bacterial Primase DnaG in Complexes with DNA Provide Insight into Key Priming Events

March 22nd, 2018 by Caixia Hou, Tapan Biswas, Oleg V. Tsodikov

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b00036

[ASAP] A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance

March 21st, 2018 by James H. Matthews, Xiao Liang, Valerie J. Paul, Hendrik Luesch

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.7b01025
  • Posted in ACS Chemical Biology, Publications
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Call for Papers: 256th ACS in Boston, MA, August 18-23, 2018

March 20th, 2018 by pthomas2

The Fall ACS Meeting in Boston will be held August 19-23, 2018. Deadline for Abstract Submission is Thursday, March 22nd at 11:59 PM EDT.
We will not be able to accept late submissions. If you are submitting a poster, we recommend that you check the box for the SciMix.

Discovery of enzymes for toluene synthesis from anoxic microbial communities

March 19th, 2018 by Harry R. Beller

Discovery of enzymes for toluene synthesis from anoxic microbial communities

Discovery of enzymes for toluene synthesis from anoxic microbial communities, Published online: 19 March 2018; doi:10.1038/s41589-018-0017-4

The source of biological toluene production in diverse anoxic microbial communities is a glycyl radical enzyme that catalyzes phenylacetate decarboxylation (PhdB), and its cognate activating radical S-adenosylmethionine enzyme (PhdA).
  • Posted in Nat Chem Biol, Publications
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Mix and match

March 19th, 2018 by Karin Kuehnel

Mix and match

Mix and match, Published online: 19 March 2018; doi:10.1038/s41589-018-0028-1

Mix and match

Structural basis for backbone N-methylation by an interrupted adenylation domain

March 19th, 2018 by Shogo Mori

Structural basis for backbone N-methylation by an interrupted adenylation domain

Structural basis for backbone N-methylation by an interrupted adenylation domain, Published online: 19 March 2018; doi:10.1038/s41589-018-0014-7

The crystal structure of a methyltransferase domain embedded within an interrupted adenylation domain provides insight into how a nonribosomal peptide synthetase N-methylates amino acid precursors for their incorporation into the peptide product.
  • Posted in Nat Chem Biol, Publications
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Whole-organism phenotypic screening for anti-infectives promoting host health

March 19th, 2018 by Anne E. Clatworthy

Whole-organism phenotypic screening for anti-infectives promoting host health

Whole-organism phenotypic screening for anti-infectives promoting host health, Published online: 19 March 2018; doi:10.1038/s41589-018-0018-3

Targeting the host during antibiotic discovery efforts is a viable strategy, and the approach has benefited from phenotypic screening of model organisms such as worms, zebrafish, and mice.
  • Posted in Nat Chem Biol, Publications
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Specialized splicing

March 19th, 2018 by Caitlin Deane

Specialized splicing

Specialized splicing, Published online: 19 March 2018; doi:10.1038/s41589-018-0027-2

Specialized splicing