Fluorescent Probes of DNA Repair

November 30th, 2017 by David L. Wilson and Eric T. Kool

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00919

Incorporation of β-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2

November 30th, 2017 by Myung-Ryul Lee, Namrata Raman, Samuel H. Gellman, David M. Lynn and Sean P. Palecek

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00843
  • Posted in ACS Chemical Biology, Publications
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Biochemical Basis of Vosevi, a New Treatment for Hepatitis C

November 29th, 2017 by Ronald Besandre and Hung-wen Liu

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Biochemistry
DOI: 10.1021/acs.biochem.7b01157

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing

November 29th, 2017 by Roger L. Williams and Madhanagopal Anandapadamanaban

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Biochemistry
DOI: 10.1021/acs.biochem.7b01120

Cell-Free and In Vivo Characterization of Lux, Las, and Rpa Quorum Activation Systems in E. coli

November 28th, 2017 by Andrew D. Halleran and Richard M. Murray

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.7b00376

5-Formylcytosine to cytosine conversion by C–C bond cleavage <i>in vivo</i>

November 27th, 2017 by Katharina Iwan

5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo

5-Formylcytosine to cytosine conversion by C–C bond cleavage <i>in vivo</i>, Published online: 27 November 2017; doi:10.1038/nchembio.2531

Direct conversion of 5-fdC into dC by C–C bond breakage is revealed by metabolic tracing studies through incorporation of synthetic stable isotope- and (R)-2′-fluorine-labeled dC and fdC derivatives into the genome of cultured mammalian cells.
  • Posted in Nat Chem Biol, Publications
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Inhibition of Delta-induced Notch signaling using fucose analogs

November 27th, 2017 by Michael Schneider

Inhibition of Delta-induced Notch signaling using fucose analogs

Inhibition of Delta-induced Notch signaling using fucose analogs, Published online: 27 November 2017; doi:10.1038/nchembio.2520

Protein O-fucosyltransferase 1 (Pofut1) regulates Notch activity by adding O-fucose residues to its extracellular domain. Fucose analogs were identified that inhibited Delta-mediated Notch binding and activation but spared Jagged1-mediated signaling.

Enzymology: I want my cluster back

November 21st, 2017 by Caitlin Deane

Enzymology: I want my cluster back

Enzymology: I want my cluster back, Published online: 21 November 2017; doi:10.1038/nchembio.2525

Enzymology: I want my cluster back

Host–pathogen interactions: A ubiquitin defense

November 21st, 2017 by Mirella Bucci

Host–pathogen interactions: A ubiquitin defense

Host–pathogen interactions: A ubiquitin defense, Published online: 21 November 2017; doi:10.1038/nchembio.2524

Host–pathogen interactions: A ubiquitin defense

Cancer systems biology: Harnessing off-target effects

November 21st, 2017 by Gaye Saginc

Cancer systems biology: Harnessing off-target effects

Cancer systems biology: Harnessing off-target effects, Published online: 21 November 2017; doi:10.1038/nchembio.2519

The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.