Target class drug discovery

September 19th, 2017 by Kimberly D Barnash

Nature Chemical Biology 13, 1053 (2017). doi:10.1038/nchembio.2473

Authors: Kimberly D Barnash, Lindsey I James & Stephen V Frye

Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complimentary approach that has higher quality outcomes in early discovery efforts.

Developmental signaling: Peaking early

September 19th, 2017 by Grant Miura

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2484

Author: Grant Miura

Bioorthogonal chemistry: Click on, click off

September 19th, 2017 by Caitlin Deane

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2482

Author: Caitlin Deane

Protein engineering: Expanding splicing versatility

September 19th, 2017 by Karin Kuehnel

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2485

Author: Karin Kuehnel

Chemical methods: DREADDs see no CNO

September 19th, 2017 by Mirella Bucci

Nature Chemical Biology 13, 1057 (2017). doi:10.1038/nchembio.2483

Author: Mirella Bucci

Detecting Activity at Different Length Scales: From Subdiffraction to Whole-Animal Activity

September 15th, 2017 by Tsz-Leung To and Xiaokun Shu

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Biochemistry
DOI: 10.1021/acs.biochem.7b00788

A New Nucleoside Antibiotic Chokes Bacterial RNA Polymerase

September 8th, 2017 by Eric P. Trautman and Jason M. Crawford

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Biochemistry
DOI: 10.1021/acs.biochem.7b00680

Ionic Strength Sensing in Living Cells

September 6th, 2017 by Boqun Liu, Bert Poolman and Arnold J. Boersma

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00348

Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8

August 30th, 2017 by Nicholas J. Porter and David W. Christianson

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ACS Chemical Biology
DOI: 10.1021/acschembio.7b00330

Oxidative cleavage of polysaccharides by monocopper enzymes depends on H2O2

August 28th, 2017 by Bastien Bissaro

Nature Chemical Biology 13, 1123 (2017). doi:10.1038/nchembio.2470

Authors: Bastien Bissaro, Åsmund K Røhr, Gerdt Müller, Piotr Chylenski, Morten Skaugen, Zarah Forsberg, Svein J Horn, Gustav Vaaje-Kolstad & Vincent G H Eijsink

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