[ASAP] Differential Post-Translational Amino Acid Isomerization Found among Neuropeptides in <italic toggle=”yes”>Aplysia californica</italic>
January 7th, 2020 by David H. Mast†, James W. Checco†‡, and Jonathan V. Sweedler*
A tunable orthogonal coiled-coil interaction toolbox for engineering mammalian cells
January 6th, 2020 by Tina Lebar
Nature Chemical Biology, Published online: 06 January 2020; doi:10.1038/s41589-019-0443-y
A set of orthogonal coiled-coil peptide heterodimers were developed to enable control of protein localization as well as transcriptional regulation by enhancing effector recruitment to TALE and CRISPR–dCas9 systems in mammalian cells and in vivo.Chain alignment of collagen I deciphered using computationally designed heterotrimers
January 6th, 2020 by Abhishek A. Jalan
Nature Chemical Biology, Published online: 06 January 2020; doi:10.1038/s41589-019-0435-y
Designed heterotrimers of collagen I, locked in three possible chain registers, enable structural and functional characterization of each permutation, leading to identification of the AAB heterotrimer as the most active and therefore likely to occur biologically.[ASAP] Molecular Dynamics Simulations of the Hypoxia-Inducible Factor PAS-B Domain Confirm That Internally Bound Water Molecules Function To Stabilize the Protein Core for Ligand Binding
January 6th, 2020 by Andrew S. Chong and Peter C. Anderson*
Publisher Correction: The chemical basis of ferroptosis
January 2nd, 2020 by Marcus Conrad
Nature Chemical Biology, Published online: 02 January 2020; doi:10.1038/s41589-019-0434-z
Publisher Correction: The chemical basis of ferroptosis[ASAP] Evolution of Substrates and Components of the Pro/N-Degron Pathway
January 2nd, 2020 by Shun-Jia Chen, Artem Melnykov†, and Alexander Varshavsky*
[ASAP] Reinforcement Learning for Bioretrosynthesis
December 30th, 2019 by
December 2019 Newsletter Released!
December 28th, 2019 by pthomas2
The December newsletter was just released. BIOL members should have received it in their email. You can find the newsletter here.
[ASAP] Tunable Repression of Key Photosynthetic Processes Using Cas12a CRISPR Interference in the Fast-Growing Cyanobacterium <italic toggle=”yes”>Synechococcus</italic> sp. UTEX 2973
December 24th, 2019 by Cory J. Knoot†, Sandeep Biswas†, and Himadri B. Pakrasi*†
An efficient gene knock-in strategy using 5′-modified double-stranded DNA donors with short homology arms
December 23rd, 2019 by Yi Yu
Nature Chemical Biology, Published online: 23 December 2019; doi:10.1038/s41589-019-0432-1
A simple and effective strategy is introduced to increase CRISPR–Cas9-mediated gene knock-in rates by using 5′-modified double-stranded DNA donors with short homology arms.