CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML
April 15th, 2019 by Michael E. Vinyard
CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML
CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML, Published online: 15 April 2019; doi:10.1038/s41589-019-0263-0
A CRISPR–Cas9 screening-based structure–activity relationship profiling method reveals that LSD1 inhibitors suppress acute myeloid leukemia by disruption of the interaction between LSD1 and GFI1B instead of the enzyme activity of LSD1.Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding
April 15th, 2019 by Masaki Okumura
Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding
Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding, Published online: 15 April 2019; doi:10.1038/s41589-019-0268-8
Single-molecule analysis by high-speed atomic force microscopy reveals that oxidized protein disulfide isomerase adopts a dynamic conformation in the absence of substrates and forms face-to-face dimers to accelerate oxidative folding in the presence of substrates.ARGuing for a new kinase class
April 8th, 2019 by Titus J. Boggon
ARGuing for a new kinase class
ARGuing for a new kinase class, Published online: 08 April 2019; doi:10.1038/s41589-019-0272-z
Arginine protein kinases regulate bacterial signaling cascades through phosphorylation of key arginine residues. Crystal structures of the kinase McsB provide the first glimpse of how these unusual enzymes recognize their protein substrates and are allosterically regulated.Structure of McsB, a protein kinase for regulated arginine phosphorylation
April 8th, 2019 by Marcin J. Suskiewicz
Structure of McsB, a protein kinase for regulated arginine phosphorylation
Structure of McsB, a protein kinase for regulated arginine phosphorylation, Published online: 08 April 2019; doi:10.1038/s41589-019-0265-y
Structural and biochemical characterization of arginine kinase McsB reveals how its phosphagen kinase–like catalytic domain is adapted to target protein substrates while its phosphoarginine-binding domain allosterically controls kinase activity.Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
April 8th, 2019 by Ayyub Ebrahimi
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming, Published online: 08 April 2019; doi:10.1038/s41589-019-0264-z
A chromatin-focused chemical screen identified CBP/EP300 bromodomain inhibitors as enhancers of reprogramming. These inhibitors decrease histone H3 lysine 27 acetylation, chromatin accessibility and expression of somatic-specific genes.Author Correction: tRNA tracking for direct measurements of protein synthesis kinetics in live cells
April 5th, 2019 by Ivan L. Volkov
Author Correction: tRNA tracking for direct measurements of protein synthesis kinetics in live cells
Author Correction: tRNA tracking for direct measurements of protein synthesis kinetics in live cells, Published online: 05 April 2019; doi:10.1038/s41589-019-0266-x
Author Correction: tRNA tracking for direct measurements of protein synthesis kinetics in live cells[ASAP] Building an Inducible T7 RNA Polymerase/T7 Promoter Circuit in <italic toggle=”yes”>Synechocystis</italic> sp. PCC6803
April 2nd, 2019 by Haojie Jin, Peter Lindblad, Devaki Bhaya
[ASAP] Combinatorial Sensor Design in <italic toggle=”yes”>Caulobacter crescentus</italic> for Selective Environmental Uranium Detection
April 2nd, 2019 by Dan M. Park, Michael J. Taffet
[ASAP] Systematic Evaluation of Genetic and Environmental Factors Affecting Performance of Translational Riboswitches
April 1st, 2019 by R. Kent, N. Dixon
[ASAP] An Accessible Continuous-Culture Turbidostat for Pooled Analysis of Complex Libraries
April 1st, 2019 by Anna M. McGeachy, Zuriah A. Meacham, Nicholas T. Ingolia
