Peroxisome compartmentalization of a toxic enzyme improves alkaloid production

October 12th, 2020 by Parbir S. Grewal

Nature Chemical Biology, Published online: 12 October 2020; doi:10.1038/s41589-020-00668-4

Increased production of (S)-reticuline and other alkaloids is achieved through alleviating norcoclaurine synthase toxicity by targeting the enzyme to the peroxisome plus enlarging peroxisomes by expression of engineered transcription factors.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Isothermal SARS-CoV-2 Diagnostics: Tools for Enabling Distributed Pandemic Testing as a Means of Supporting Safe Reopenings

October 8th, 2020 by Pavana Khan, Lauren M. Aufdembrink, and Aaron E. Engelhart

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00359
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[ASAP] Reading and Writing Digital Information in TNA

October 7th, 2020 by Kefan Yang, Cailen M. McCloskey, and John C. Chaput

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00361

[ASAP] Conditional Protein Rescue by Binding-Induced Protective Shielding

October 6th, 2020 by Andrew S. Gaynor and Wilfred Chen

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00367

Discovery of iron-sensing bacterial riboswitches

October 5th, 2020 by Siladitya Bandyopadhyay

Nature Chemical Biology, Published online: 05 October 2020; doi:10.1038/s41589-020-00665-7

A family of riboswitches named Sensei that specifically sense iron has been discovered and characterized, which enables the authors to engineer metal ion sensing riboswitches to convert their metal selectivity.

Sulfated glycans engage the Ang–Tie pathway to regulate vascular development

October 5th, 2020 by Matthew E. Griffin

Nature Chemical Biology, Published online: 05 October 2020; doi:10.1038/s41589-020-00657-7

A chemical glycobiology approach reveals that heparan-sulfate glycosaminoglycans regulate vascular development through direct interactions with angiopoietin (Ang) ligands and the Tie1 receptor of the Ang–Tie signaling system.
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[ASAP] Delineating Heme-Mediated versus Direct Protein Oxidation in Peroxidase-Activated Cytochrome <italic toggle=”yes”>c</italic> by Top-Down Mass Spectrometry

October 4th, 2020 by Victor Yin, Derek Holzscherer, and Lars Konermann

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Biochemistry
DOI: 10.1021/acs.biochem.0c00609

[ASAP] Structure Activity Relationship Study of the XIP Quorum Sensing Pheromone in <italic toggle=”yes”>Streptococcus mutans</italic> Reveal Inhibitors of the Competence Regulon

October 1st, 2020 by Chowdhury Raihan Bikash and Yftah Tal-Gan

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ACS Chemical Biology
DOI: 10.1021/acschembio.0c00650
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CueR activates transcription through a DNA distortion mechanism

September 28th, 2020 by Chengli Fang

Nature Chemical Biology, Published online: 28 September 2020; doi:10.1038/s41589-020-00653-x

Structural analysis of transcription activation complex comprising E. coli transcription factor CueR, RNAP holoenzyme and promoter DNA reveals that CueR distorts the DNA conformation to promote the association of promoter with polymerase.

Glucosylation prevents plant defense activation in phloem-feeding insects

September 28th, 2020 by Osnat Malka

Nature Chemical Biology, Published online: 28 September 2020; doi:10.1038/s41589-020-00658-6

The whitefly Bemisia tabaci defends against plant glucosinolate toxins by serial addition of glucose moieties catalyzed by a pair of glycoside hydrolases, preventing toxin activation during feeding on the plant tissue.
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