Peroxisome compartmentalization of a toxic enzyme improves alkaloid production
October 12th, 2020 by Parbir S. Grewal
Nature Chemical Biology, Published online: 12 October 2020; doi:10.1038/s41589-020-00668-4
Increased production of (S)-reticuline and other alkaloids is achieved through alleviating norcoclaurine synthase toxicity by targeting the enzyme to the peroxisome plus enlarging peroxisomes by expression of engineered transcription factors.[ASAP] Isothermal SARS-CoV-2 Diagnostics: Tools for Enabling Distributed Pandemic Testing as a Means of Supporting Safe Reopenings
October 8th, 2020 by Pavana Khan, Lauren M. Aufdembrink, and Aaron E. Engelhart
[ASAP] Reading and Writing Digital Information in TNA
October 7th, 2020 by Kefan Yang, Cailen M. McCloskey, and John C. Chaput
[ASAP] Conditional Protein Rescue by Binding-Induced Protective Shielding
October 6th, 2020 by Andrew S. Gaynor and Wilfred Chen
Discovery of iron-sensing bacterial riboswitches
October 5th, 2020 by Siladitya Bandyopadhyay
Nature Chemical Biology, Published online: 05 October 2020; doi:10.1038/s41589-020-00665-7
A family of riboswitches named Sensei that specifically sense iron has been discovered and characterized, which enables the authors to engineer metal ion sensing riboswitches to convert their metal selectivity.Sulfated glycans engage the Ang–Tie pathway to regulate vascular development
October 5th, 2020 by Matthew E. Griffin
Nature Chemical Biology, Published online: 05 October 2020; doi:10.1038/s41589-020-00657-7
A chemical glycobiology approach reveals that heparan-sulfate glycosaminoglycans regulate vascular development through direct interactions with angiopoietin (Ang) ligands and the Tie1 receptor of the Ang–Tie signaling system.[ASAP] Delineating Heme-Mediated versus Direct Protein Oxidation in Peroxidase-Activated Cytochrome <italic toggle=”yes”>c</italic> by Top-Down Mass Spectrometry
October 4th, 2020 by Victor Yin, Derek Holzscherer, and Lars Konermann
[ASAP] Structure Activity Relationship Study of the XIP Quorum Sensing Pheromone in <italic toggle=”yes”>Streptococcus mutans</italic> Reveal Inhibitors of the Competence Regulon
October 1st, 2020 by Chowdhury Raihan Bikash and Yftah Tal-Gan
CueR activates transcription through a DNA distortion mechanism
September 28th, 2020 by Chengli Fang
Nature Chemical Biology, Published online: 28 September 2020; doi:10.1038/s41589-020-00653-x
Structural analysis of transcription activation complex comprising E. coli transcription factor CueR, RNAP holoenzyme and promoter DNA reveals that CueR distorts the DNA conformation to promote the association of promoter with polymerase.Glucosylation prevents plant defense activation in phloem-feeding insects
September 28th, 2020 by Osnat Malka
Nature Chemical Biology, Published online: 28 September 2020; doi:10.1038/s41589-020-00658-6
The whitefly Bemisia tabaci defends against plant glucosinolate toxins by serial addition of glucose moieties catalyzed by a pair of glycoside hydrolases, preventing toxin activation during feeding on the plant tissue.