Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes

June 25th, 2018 by Thu-Thuy T. Dang

Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes

Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes, Published online: 25 June 2018; doi:10.1038/s41589-018-0078-4

Three homologous cytochrome P450s from monoterpene indole alkaloid-producing plants enable the identification of sarpagan bridge enzyme, which catalyzes either cyclization or aromatization to yield sarpagan or β-carboline alkaloids, respectively.
  • Posted in Nat Chem Biol, Publications
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Designing microbial consortia with defined social interactions

June 25th, 2018 by Wentao Kong

Designing microbial consortia with defined social interactions

Designing microbial consortia with defined social interactions, Published online: 25 June 2018; doi:10.1038/s41589-018-0091-7

Synthetic microbial consortia were engineered as experimental models of bacterial interactions within ecosystems, and mathematical models of their behavior were used to design more complex microbial systems with additional interactions.

[ASAP] A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation

June 21st, 2018 by Jan-Erik Hoffmann, Dmytro Dziuba, Frank Stein, Carsten Schultz

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b00397

[ASAP] So Close, yet Sulfur Away: Opening the Nitrogenase Cofactor Structure Creates a Binding Site

June 20th, 2018 by Kazimer L. Skubi, Patrick L. Holland

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.8b00529

Stabilizing synapsis

June 18th, 2018 by Yiyun Song

Stabilizing synapsis

Stabilizing synapsis, Published online: 18 June 2018; doi:10.1038/s41589-018-0095-3

Stabilizing synapsis

Tricks for taking up residence

June 18th, 2018 by Mirella Bucci

Tricks for taking up residence

Tricks for taking up residence, Published online: 18 June 2018; doi:10.1038/s41589-018-0094-4

Tricks for taking up residence

Please hold for chaperones

June 18th, 2018 by Caitlin Deane

Please hold for chaperones

Please hold for chaperones, Published online: 18 June 2018; doi:10.1038/s41589-018-0092-6

Please hold for chaperones

Vitamin B<sub>12</sub> import is all about timing

June 18th, 2018 by Lutz Schmitt

Vitamin B12 import is all about timing

Vitamin B<sub>12</sub> import is all about timing, Published online: 18 June 2018; doi:10.1038/s41589-018-0087-3

Single-molecule techniques combined with molecular dynamics simulations allowed visualization of a surprisingly high level of conformational homogeneity in the transport cycle of an ABC import system, BtuCD-F, and revealed an unexpected tight coupling of distinct conformational states responsible for vitamin B12 binding, transport and release.

The Jumonji-C oxygenase JMJD7 catalyzes (3<i>S</i>)-lysyl hydroxylation of TRAFAC GTPases

June 18th, 2018 by Suzana Markolovic

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

The Jumonji-C oxygenase JMJD7 catalyzes (3<i>S</i>)-lysyl hydroxylation of TRAFAC GTPases, Published online: 18 June 2018; doi:10.1038/s41589-018-0071-y

Structural, biochemical and cellular studies reveal JMJD7 to be a Jumonji-C oxygenase that catalyzes (3S)-lysyl hydroxylation of the translation factor family of GTPases, DRG1 and DRG2.
  • Posted in Nat Chem Biol, Publications
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The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides

June 18th, 2018 by Vincent Wiebach

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides, Published online: 18 June 2018; doi:10.1038/s41589-018-0068-6

The antibacterial microvionin contains two new lanthipeptide modifications, a triamino-dicarboxylic acid (avionin) and an N-terminal guanidino fatty acid, that lead to the establishment of the lipolanthine natural product class.
  • Posted in Nat Chem Biol, Publications
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