[ASAP] Differential Post-Translational Amino Acid Isomerization Found among Neuropeptides in <italic toggle=”yes”>Aplysia californica</italic>

January 7th, 2020 by David H. Mast†, James W. Checco†‡, and Jonathan V. Sweedler*

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ACS Chemical Biology
DOI: 10.1021/acschembio.9b00910
  • Posted in ACS Chemical Biology, Publications
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A tunable orthogonal coiled-coil interaction toolbox for engineering mammalian cells

January 6th, 2020 by Tina Lebar

Nature Chemical Biology, Published online: 06 January 2020; doi:10.1038/s41589-019-0443-y

A set of orthogonal coiled-coil peptide heterodimers were developed to enable control of protein localization as well as transcriptional regulation by enhancing effector recruitment to TALE and CRISPR–dCas9 systems in mammalian cells and in vivo.
  • Posted in Nat Chem Biol, Publications
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Chain alignment of collagen I deciphered using computationally designed heterotrimers

January 6th, 2020 by Abhishek A. Jalan

Nature Chemical Biology, Published online: 06 January 2020; doi:10.1038/s41589-019-0435-y

Designed heterotrimers of collagen I, locked in three possible chain registers, enable structural and functional characterization of each permutation, leading to identification of the AAB heterotrimer as the most active and therefore likely to occur biologically.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Molecular Dynamics Simulations of the Hypoxia-Inducible Factor PAS-B Domain Confirm That Internally Bound Water Molecules Function To Stabilize the Protein Core for Ligand Binding

January 6th, 2020 by Andrew S. Chong and Peter C. Anderson*

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Biochemistry
DOI: 10.1021/acs.biochem.9b00872

Publisher Correction: The chemical basis of ferroptosis

January 2nd, 2020 by Marcus Conrad

Nature Chemical Biology, Published online: 02 January 2020; doi:10.1038/s41589-019-0434-z

Publisher Correction: The chemical basis of ferroptosis

[ASAP] Evolution of Substrates and Components of the Pro/N-Degron Pathway

January 2nd, 2020 by Shun-Jia Chen, Artem Melnykov†, and Alexander Varshavsky*

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Biochemistry
DOI: 10.1021/acs.biochem.9b00953

[ASAP] Reinforcement Learning for Bioretrosynthesis

December 30th, 2019 by

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00447

December 2019 Newsletter Released!

December 28th, 2019 by pthomas2

The December newsletter was just released. BIOL members should have received it in their email. You can find the newsletter here.

  • Posted in DBC News
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[ASAP] Tunable Repression of Key Photosynthetic Processes Using Cas12a CRISPR Interference in the Fast-Growing Cyanobacterium <italic toggle=”yes”>Synechococcus</italic> sp. UTEX 2973

December 24th, 2019 by Cory J. Knoot†, Sandeep Biswas†, and Himadri B. Pakrasi*†

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00417
  • Posted in ACS Synthetic Biology, Publications
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An efficient gene knock-in strategy using 5′-modified double-stranded DNA donors with short homology arms

December 23rd, 2019 by Yi Yu

Nature Chemical Biology, Published online: 23 December 2019; doi:10.1038/s41589-019-0432-1

A simple and effective strategy is introduced to increase CRISPR–Cas9-mediated gene knock-in rates by using 5′-modified double-stranded DNA donors with short homology arms.
  • Posted in Nat Chem Biol, Publications
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