Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer

October 30th, 2017 by Yi Qu

Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer

Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer, Published online: 30 October 2017; doi:10.1038/nchembio.2510

NatureArticleSnippet(type=short-summary, markup=

The small molecule nitazoxanide (NTZ) was identified as a Wnt inhibitor by promoting protein citrullination of β-catenin through increased cytosolic calcium and PAD2 protein stabilization. β-catenin citrullination results in proteasomal degradation.

, isJats=true)
  • Posted in Nat Chem Biol, Publications
  • Comments Off on Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer

PatB1 is an <i>O</i>-acetyltransferase that decorates secondary cell wall polysaccharides

October 30th, 2017 by David Sychantha

PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides

PatB1 is an <i>O</i>-acetyltransferase that decorates secondary cell wall polysaccharides, Published online: 30 October 2017; doi:10.1038/nchembio.2509

NatureArticleSnippet(type=short-summary, markup=

A chemically synthesized analog of Bacillus cereus secondary cell wall polysaccharide (SCWP) facilitates the identification of PatB1 as a SCWP O-acetyltransferase, and the structure of PatB1 provides insights into its catalytic mechanism.

, isJats=true)
  • Posted in Nat Chem Biol, Publications
  • Comments Off on PatB1 is an <i>O</i>-acetyltransferase that decorates secondary cell wall polysaccharides

Synthetic beta cells for fusion-mediated dynamic insulin secretion

October 30th, 2017 by Zhaowei Chen

Synthetic beta cells for fusion-mediated dynamic insulin secretion

Synthetic beta cells for fusion-mediated dynamic insulin secretion, Published online: 30 October 2017; doi:10.1038/nchembio.2511

NatureArticleSnippet(type=short-summary, markup=

Synthetic beta cells were fabricated through 'vesicles-in-vesicle' liposomal superstructures equipped with glucose-sensing and membrane-fusion machinery, thus enabling sensing of graded glucose levels and secretion of insulin via fusion processes.

, isJats=true)

The Conformational Change in Elongation Factor Tu Involves Separation of Its Domains

October 27th, 2017 by Jonathan Lai, Zhaleh Ghaemi and Zaida Luthey-Schulten

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.7b00591

Correction to Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

October 27th, 2017 by Srinivasaraghavan Kannan, Anders Poulsen, Hai Yan Yang, Melvyn Ho, Shi Hua Ang, Tan Sum Wai Eldwin, Duraiswamy Athisayamani Jeyaraj, Lohitha Rao Chennamaneni, Boping Liu, Jeffrey Hill, Chandra S. Verma and Kassoum Nacro

Biochemistry
DOI: 10.1021/acs.biochem.7b00996

Structural and Functional Effects of Cytochrome b5 Interactions with Human Cytochrome P450 Enzymes [Enzymology]

October 27th, 2017 by Aaron G. Bart, Emily E. Scott

The small heme-containing protein cytochrome b5 can facilitate, inhibit, or have no effect on cytochrome P450 catalysis, often in a P450-dependent and substrate-dependent manner that is not well understood. Herein solution NMR was used to identify b5 residues interacting with different human drug-metabolizing P450 enzymes. NMR results revealed that P450 enzymes bound to either b5 α4-5 (CYP2A6 and CYP2E1) or this region and α2-3 (CYP2D6 and CYP3A4) and suggested variation in the affinity for b5. Mutations of key b5 residues suggest that not only are different b5 surfaces responsible for binding different P450 enzymes, but that these different complexes are relevant to the observed effects on P450 catalysis.

The G126V Mutation in the Mouse Prion Protein Hinders Nucleation-Dependent Fibril Formation by Slowing Initial Fibril Growth and by Increasing the Critical Concentration

October 26th, 2017 by Ambadi Thody Sabareesan and Jayant B. Udgaonkar

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.7b00894

Next-Generation Photodynamic Therapy: New Probes for Cancer Imaging and Treatment

October 26th, 2017 by Andrew A. Beharry

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.7b01037

Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning

October 26th, 2017 by Haobo Wang, Xuemin Chen, Can Li, Yuan Liu, Fan Yang and Chu Wang

TOC Graphic

Biochemistry
DOI: 10.1021/acs.biochem.7b00897

CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine

October 24th, 2017 by Martin Kampmann

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.7b00657