Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes
June 25th, 2018 by Thu-Thuy T. Dang
Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes
Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes, Published online: 25 June 2018; doi:10.1038/s41589-018-0078-4
Three homologous cytochrome P450s from monoterpene indole alkaloid-producing plants enable the identification of sarpagan bridge enzyme, which catalyzes either cyclization or aromatization to yield sarpagan or β-carboline alkaloids, respectively.Designing microbial consortia with defined social interactions
June 25th, 2018 by Wentao Kong
Designing microbial consortia with defined social interactions
Designing microbial consortia with defined social interactions, Published online: 25 June 2018; doi:10.1038/s41589-018-0091-7
Synthetic microbial consortia were engineered as experimental models of bacterial interactions within ecosystems, and mathematical models of their behavior were used to design more complex microbial systems with additional interactions.[ASAP] A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation
June 21st, 2018 by Jan-Erik Hoffmann, Dmytro Dziuba, Frank Stein, Carsten Schultz
[ASAP] So Close, yet Sulfur Away: Opening the Nitrogenase Cofactor Structure Creates a Binding Site
June 20th, 2018 by Kazimer L. Skubi, Patrick L. Holland
Stabilizing synapsis
June 18th, 2018 by Yiyun Song
Stabilizing synapsis
Stabilizing synapsis, Published online: 18 June 2018; doi:10.1038/s41589-018-0095-3
Stabilizing synapsisTricks for taking up residence
June 18th, 2018 by Mirella Bucci
Tricks for taking up residence
Tricks for taking up residence, Published online: 18 June 2018; doi:10.1038/s41589-018-0094-4
Tricks for taking up residencePlease hold for chaperones
June 18th, 2018 by Caitlin Deane
Please hold for chaperones
Please hold for chaperones, Published online: 18 June 2018; doi:10.1038/s41589-018-0092-6
Please hold for chaperonesVitamin B<sub>12</sub> import is all about timing
June 18th, 2018 by Lutz Schmitt
Vitamin B12 import is all about timing
Vitamin B<sub>12</sub> import is all about timing, Published online: 18 June 2018; doi:10.1038/s41589-018-0087-3
Single-molecule techniques combined with molecular dynamics simulations allowed visualization of a surprisingly high level of conformational homogeneity in the transport cycle of an ABC import system, BtuCD-F, and revealed an unexpected tight coupling of distinct conformational states responsible for vitamin B12 binding, transport and release.The Jumonji-C oxygenase JMJD7 catalyzes (3<i>S</i>)-lysyl hydroxylation of TRAFAC GTPases
June 18th, 2018 by Suzana Markolovic
The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases
The Jumonji-C oxygenase JMJD7 catalyzes (3<i>S</i>)-lysyl hydroxylation of TRAFAC GTPases, Published online: 18 June 2018; doi:10.1038/s41589-018-0071-y
Structural, biochemical and cellular studies reveal JMJD7 to be a Jumonji-C oxygenase that catalyzes (3S)-lysyl hydroxylation of the translation factor family of GTPases, DRG1 and DRG2.The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides
June 18th, 2018 by Vincent Wiebach
The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides
The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides, Published online: 18 June 2018; doi:10.1038/s41589-018-0068-6
The antibacterial microvionin contains two new lanthipeptide modifications, a triamino-dicarboxylic acid (avionin) and an N-terminal guanidino fatty acid, that lead to the establishment of the lipolanthine natural product class.