Mechanism of regulation and neutralization of the AtaR–AtaT toxin–antitoxin system

February 4th, 2019 by Dukas Jurėnas

Mechanism of regulation and neutralization of the AtaR–AtaT toxin–antitoxin system

Mechanism of regulation and neutralization of the AtaR–AtaT toxin–antitoxin system, Published online: 04 February 2019; doi:10.1038/s41589-018-0216-z

Structural and biochemical analysis of the AtaR–AtaT toxin–antioxin system reveals that AtaR traps AtaT in a precatalytic monomeric state and forms a heterohexameric complex to neutralize AtaT and repress transcription of the operon.
  • Posted in Nat Chem Biol, Publications
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A class of highly selective inhibitors bind to an active state of PI3Kγ

February 4th, 2019 by Gangadhara Gangadhara

A class of highly selective inhibitors bind to an active state of PI3Kγ

A class of highly selective inhibitors bind to an active state of PI3Kγ, Published online: 04 February 2019; doi:10.1038/s41589-018-0215-0

Combining X-ray structures, surface plasmon resonance and hydrogen-deuterium exchange–mass spectrometry, a class of highly selective inhibitors was found to bind to an active state of PI3Kγ breaking a conformational ‘lock’ important for activation of PI3Kγ.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Chemical Diversification Based on Substrate Promiscuity of a Standalone Adenylation Domain in a Reconstituted NRPS System

February 4th, 2019 by Mengyi Zhu, Lijuan Wang, Jing He

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ACS Chemical Biology
DOI: 10.1021/acschembio.8b00938
  • Posted in ACS Chemical Biology, Publications
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[ASAP] <italic toggle=”yes”>N</italic>-Acyl <sc>l</sc>-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in <italic toggle=”yes”>Pseudomonas aeruginosa</italic>

February 1st, 2019 by Michelle E. Boursier, Joshua B. Combs, Helen E. Blackwell

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ACS Chemical Biology
DOI: 10.1021/acschembio.8b01079
  • Posted in ACS Chemical Biology, Publications
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[ASAP] Metabolic Regulation of the Epitranscriptome

February 1st, 2019 by Justin M. Thomas, Pedro J. Batista, Jordan L. Meier

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ACS Chemical Biology
DOI: 10.1021/acschembio.8b00951

[ASAP] Antisense RNA-Based Strategy for Enhancing Surfactin Production in <italic toggle=”yes”>Bacillus subtilis</italic> TS1726 via Overexpression of the Unconventional Biotin Carboxylase II To Enhance ACCase Activity

January 31st, 2019 by Miaomiao Wang, Huimin Yu, Zhongyao Shen

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00459
  • Posted in ACS Synthetic Biology, Publications
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An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

January 28th, 2019 by Jean Quancard

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient, Published online: 28 January 2019; doi:10.1038/s41589-018-0222-1

An allosteric inhibitor of the proteolytic activity of the CBM signalosome complex scaffolding protein MALT1 acts as a pharmacological chaperone to stabilize a mutant MALT1 carried by an immunodeficient patient.
  • Posted in Nat Chem Biol, Publications
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Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL

January 28th, 2019 by Christian Schmidl

Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL

Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL, Published online: 28 January 2019; doi:10.1038/s41589-018-0205-2

Epigenome profiling in combination with imaging-based chemosensitivity and integrative bioinformatic analysis establishes a method for detecting therapy-induced vulnerabilities, as shown here for ibrutinib-treated chronic lymphocytic leukemia.
  • Posted in Nat Chem Biol, Publications
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Bacterial sensors define intracellular free energies for correct enzyme metalation

January 28th, 2019 by Deenah Osman

Bacterial sensors define intracellular free energies for correct enzyme metalation

Bacterial sensors define intracellular free energies for correct enzyme metalation, Published online: 28 January 2019; doi:10.1038/s41589-018-0211-4

The sensitivities of a set of bacterial metal-sensing transcriptional regulators explain how a protein, such as the cobalt chelatase CbiK, is metalated with its cognate metal in cells rather than mis-metalated with more tightly binding metals.
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Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum

January 21st, 2019 by Xiaoxue Zhou

Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum

Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum, Published online: 21 January 2019; doi:10.1038/s41589-018-0206-1

Assembly of the mycobacterial cell envelope layers, including peptidoglycan (PG) and the mycomembrane (MM), is synchronous during elongation, when a mobile fraction of the MM diffuses into the septum after thinning of the diffusion barrier formed by PG.
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