[ASAP] <italic toggle=”yes”>In Silico</italic> Protein Design Promotes the Rapid Evolution of Industrial Enzymes

September 20th, 2018 by Yang Wang, Jian Chen, Zhen Kang

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Biochemistry
DOI: 10.1021/acs.biochem.8b00896

[ASAP] Enhancing Light-Driven 1,3-Propanediol Production by Using Natural Compartmentalization of Differentiated Cells

September 19th, 2018 by Hongyu Liu, Jun Ni, Ping Xu, Fei Tao

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.8b00239
  • Posted in ACS Synthetic Biology, Publications
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[ASAP] Interactions of the DNA Repair Enzyme Human Thymine DNA Glycosylase with Cognate and Noncognate DNA

September 19th, 2018 by Natalia Kanaan, Petra Imhof

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Biochemistry
DOI: 10.1021/acs.biochem.8b00409

[ASAP] New Crystallographic Snapshots of Large Domain Movements in Bacterial 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

September 18th, 2018 by Edwin R. Ragwan, Eri Arai, Yan Kung

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Biochemistry
DOI: 10.1021/acs.biochem.8b00869

Diversifying bases

September 17th, 2018 by Yiyun Song

Diversifying bases

Diversifying bases, Published online: 17 September 2018; doi:10.1038/s41589-018-0141-1

Diversifying bases

Flipping out the peptide

September 17th, 2018 by Stephanie Gras

Flipping out the peptide

Flipping out the peptide, Published online: 17 September 2018; doi:10.1038/s41589-018-0133-1

T cell cross-reactivity enables the immune system to recognize a large array of peptides. A new study shows that T cells can achieve cross-recognition by using the remarkable plasticity of peptides, through flipping the peptide out of the binding cleft.

Fatal chemoattraction

September 17th, 2018 by Mirella Bucci

Fatal chemoattraction

Fatal chemoattraction, Published online: 17 September 2018; doi:10.1038/s41589-018-0140-2

Fatal chemoattraction

The substrate lends a hand

September 17th, 2018 by Albert A. Bowers

The substrate lends a hand

The substrate lends a hand, Published online: 17 September 2018; doi:10.1038/s41589-018-0135-z

Duramycin is a small post-translationally modified peptide with antibody-like affinity for phosphatidylethanolamine. As it turns out, the same functionality that is essential for duramycin activity helps to catalyze the formation of its conformationally constrained and compact polycyclic architecture.

Post-translational site-selective protein backbone α-deuteration

September 17th, 2018 by Sébastien R. G. Galan

Post-translational site-selective protein backbone α-deuteration

Post-translational site-selective protein backbone α-deuteration, Published online: 17 September 2018; doi:10.1038/s41589-018-0128-y

A chemical method for site-selective deuterium exchange at protein backbone α-carbons, involving conversion of cysteine to dehydroalanine and then to deuterated cysteine, is used to explore the mechanism of a model protein bioconjugation reaction.

T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability

September 17th, 2018 by Timothy P. Riley

T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability

T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability, Published online: 17 September 2018; doi:10.1038/s41589-018-0130-4

Structural analysis shows that cross-reactivity of the T cell receptor DMF5 is governed by adaptability of the peptide antigen, which can undergo TCR-binding-induced frameshifting forcing the peptide C terminus to extend from the MHC-binding groove.
  • Posted in Nat Chem Biol, Publications
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