Characterization of 1,2-Propanediol Dehydratases Reveals Distinct Mechanisms for B12-Dependent and Glycyl Radical Enzymes

March 16th, 2018 by Benjamin J. Levin and Emily P. Balskus

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Biochemistry
DOI: 10.1021/acs.biochem.8b00164

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis

March 12th, 2018 by Sean A. Newmister

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis

Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis, Published online: 12 March 2018; doi:10.1038/s41589-018-0003-x

The structure of a Stig cyclase, HpiC1, reveals how it catalyzes Cope rearrangement and 6-exo-trig cyclization, including how it controls the position of electrophilic aromatic substation that distinguishes hapalindole from fischerindole alkaloids.
  • Posted in Nat Chem Biol, Publications
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Photophysical Tuning of N-Oxide-Based Probes Enables Ratiometric Photoacoustic Imaging of Tumor Hypoxia

March 9th, 2018 by Hailey J. Knox, Tae Wook Kim, Zhouyang Zhu and Jefferson Chan

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ACS Chemical Biology
DOI: 10.1021/acschembio.8b00099
  • Posted in ACS Chemical Biology, Publications
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Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

March 8th, 2018 by Kiryl D. Piatkevich

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters, Published online: 08 March 2018; doi:10.1038/s41589-018-0023-6

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters
  • Posted in Nat Chem Biol, Publications
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Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

March 8th, 2018 by Lukas Reisky

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases, Published online: 08 March 2018; doi:10.1038/s41589-018-0020-9

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases
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Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by <span class=”small-caps”>d</span>-stereospecific peptidases

March 7th, 2018 by Yong-Xin Li

Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases

Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by <span class="small-caps">d</span>-stereospecific peptidases, Published online: 07 March 2018; doi:10.1038/s41589-018-0022-7

Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases
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Folding against the wind

March 5th, 2018 by Frederick Stull

Folding against the wind

Folding against the wind, Published online: 05 March 2018; doi:10.1038/s41589-018-0016-5

Many thermodynamically unfavorable processes in biology are powered by ATP, the energy currency of the cell. New evidence suggests that chaperone-mediated protein stabilization may need to be added to that list.

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL

March 5th, 2018 by Ariele Viacava Follis

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL, Published online: 05 March 2018; doi:10.1038/s41589-018-0011-x

Post-translational modification of residues in an intrinsically disordered region of Bcl-XL promotes interactions with its folded core and allosterically reduces affinity for proapoptotic BH3-domain-containing proteins, resulting in apoptosis.
  • Posted in Nat Chem Biol, Publications
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A lanthipeptide library used to identify a protein–protein interaction inhibitor

March 5th, 2018 by Xiao Yang

A lanthipeptide library used to identify a protein–protein interaction inhibitor

A lanthipeptide library used to identify a protein–protein interaction inhibitor, Published online: 05 March 2018; doi:10.1038/s41589-018-0008-5

The substrate-tolerant lanthipeptide synthetase ProcM enables the construction of a plasmid-encoded library of bicyclic lanthipeptides, from which an inhibitor of the p6–UEV protein–protein interaction is identified by a reverse two-hybrid screen.
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Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

March 5th, 2018 by Lara N. Gechijian

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands, Published online: 05 March 2018; doi:10.1038/s41589-018-0010-y

Selective TRIM24 degradation is achieved by co-opting the VHL E3 ubiquitin ligase machinery. TRIM24 degradation outperforms bromodomain inhibition, with an enhanced antiproliferative effect in acute leukemia, a novel context of TRIM24 dependency.
  • Posted in Nat Chem Biol, Publications
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