Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells

July 9th, 2018 by Youngnam N. Jin

Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells

Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells, Published online: 09 July 2018; doi:10.1038/s41589-018-0098-0

Primordazine inhibits poly(A)-tail-independent noncanonical translation (PAINT) in early zebrafish embryos and in mammalian cells under select conditions, an effect mediated by deadenylated 3ʹ UTRs that results in ablation of primordial germ cells.
  • Posted in Nat Chem Biol, Publications
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PAINTing translation

July 9th, 2018 by Yuichiro Mishima

PAINTing translation

PAINTing translation, Published online: 09 July 2018; doi:10.1038/s41589-018-0102-8

Establishment of the germ cell lineage requires post-transcriptional regulation of mRNAs, yet the underlying molecular mechanisms are not fully understood in vertebrates. A small-molecule inhibitor of germ cell formation reveals a noncanonical translation system used in zebrafish embryos.

Fall ACS 2018 BIOL Program Summary Released

July 5th, 2018 by pthomas2

The Program Summary and schedule for the Fall ACS 2018 BIOL Program has been released and can be downloaded here.

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Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3<i>S</i>)-lysyl hydroxylation of TRAFAC GTPases

June 27th, 2018 by Suzana Markolovic

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3<i>S</i>)-lysyl hydroxylation of TRAFAC GTPases, Published online: 27 June 2018; doi:10.1038/s41589-018-0104-6

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases
  • Posted in Nat Chem Biol, Publications
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[ASAP] Optical Recording of Zn<sup>2+</sup> Dynamics in the Mitochondrial Matrix and Intermembrane Space with the GZnP2 Sensor

June 25th, 2018 by Dylan H. Fudge, Raymond Black, Lea Son, Kate LeJeune, Yan Qin

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.8b00319
  • Posted in ACS Chemical Biology, Publications
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Unraveling the rewired network

June 25th, 2018 by Vinayak Palve

Unraveling the rewired network

Unraveling the rewired network, Published online: 25 June 2018; doi:10.1038/s41589-018-0083-7

Adaptive survival signaling can promote resistance to individual kinase inhibitors. A new study used a pathway-based approach to characterize shared kinome-wide rewiring mechanisms across multiple kinase inhibitors and developed rational drug-combination approaches that target cross-talk between two signaling pathways.

Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer

June 25th, 2018 by Hayley J. Donnella

Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer

Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer, Published online: 25 June 2018; doi:10.1038/s41589-018-0081-9

Proteomic mapping of dynamic changes in kinase signaling after drug treatment identifies that AURKA inhibition is required for drug sensitivity, representing a new co-targeting opportunity with PI3K, AKT, or mTOR inhibitors in breast cancer.
  • Posted in Nat Chem Biol, Publications
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Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase

June 25th, 2018 by Jiasong Li

Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase

Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase, Published online: 25 June 2018; doi:10.1038/s41589-018-0085-5

Engineered variants of cysteine dioxygenase containing a halogen-substituted tyrosine analog provide insights into the process of Cys–Tyr cross-link formation and indicate that the enzyme can catalyze oxidative cleavage of a carbon–fluorine bond.
  • Posted in Nat Chem Biol, Publications
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Metabolic engineering of a carbapenem antibiotic synthesis pathway in <i>Escherichia coli</i>

June 25th, 2018 by Helena Shomar

Metabolic engineering of a carbapenem antibiotic synthesis pathway in Escherichia coli

Metabolic engineering of a carbapenem antibiotic synthesis pathway in <i>Escherichia coli</i>, Published online: 25 June 2018; doi:10.1038/s41589-018-0084-6

Efficient production of a simple carbapenem antibiotic in Escherichia coli is achieved by a combination of feedback-resistant enzymes for increased precursor biosynthesis and inhibition of fatty acid synthesis for tolerance toward the toxic product.
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Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes

June 25th, 2018 by Thu-Thuy T. Dang

Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes

Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes, Published online: 25 June 2018; doi:10.1038/s41589-018-0078-4

Three homologous cytochrome P450s from monoterpene indole alkaloid-producing plants enable the identification of sarpagan bridge enzyme, which catalyzes either cyclization or aromatization to yield sarpagan or β-carboline alkaloids, respectively.
  • Posted in Nat Chem Biol, Publications
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