[ASAP] Transferrin Cycle and Clinical Roles of Citrate and Ascorbate in Improved Iron Metabolism
April 23rd, 2019 by Aviva Levina, Peter A. Lay
Disruption of endocytosis through chemical inhibition of clathrin heavy chain function
April 22nd, 2019 by Wim Dejonghe
Disruption of endocytosis through chemical inhibition of clathrin heavy chain function
Disruption of endocytosis through chemical inhibition of clathrin heavy chain function, Published online: 22 April 2019; doi:10.1038/s41589-019-0262-1
Affinity-based target isolation and X-ray crystallography enabled identification of the non-protonophore ES9-17 as an inhibitor of the clathrin heavy chain in plants, enabling disruption of endocytosis.Braking plant endocytosis
April 22nd, 2019 by Chunhua Zhang
Braking plant endocytosis
Braking plant endocytosis, Published online: 22 April 2019; doi:10.1038/s41589-019-0273-y
Endocytosis mediates the internalization of proteins and lipids at the plasma membrane and plays essential roles in plant growth and development. A new small molecule enables manipulation of plant endocytosis in an acute and transient manner.Marking histones
April 16th, 2019 by Yiyun Song
Marking histones
Marking histones, Published online: 16 April 2019; doi:10.1038/s41589-019-0283-9
Marking histonesCannabinoids on the rise
April 16th, 2019 by Caitlin Deane
Cannabinoids on the rise
Cannabinoids on the rise, Published online: 16 April 2019; doi:10.1038/s41589-019-0280-z
Cannabinoids on the riseScaffold and organism hopping with chemical probes
April 16th, 2019 by Jürg Gertsch
Scaffold and organism hopping with chemical probes
Scaffold and organism hopping with chemical probes, Published online: 16 April 2019; doi:10.1038/s41589-019-0275-9
Chemical probes that irreversibly inhibit protein function may be used across species to discover proteins. Combining phenotypic screening and activity-based protein profiling, a new study uncovers a discrete lipid signaling pathway regulating lifespan in the worm Caenorhabditis elegans.Under pressure
April 16th, 2019 by Grant Miura
Under pressure
Under pressure, Published online: 16 April 2019; doi:10.1038/s41589-019-0282-x
Under pressureAvoiding the dumpster
April 16th, 2019 by Grant Miura
Avoiding the dumpster
Avoiding the dumpster, Published online: 16 April 2019; doi:10.1038/s41589-019-0281-y
Avoiding the dumpsterStructure and functional reselection of the Mango-III fluorogenic RNA aptamer
April 15th, 2019 by Robert J. Trachman III
Structure and functional reselection of the Mango-III fluorogenic RNA aptamer
Structure and functional reselection of the Mango-III fluorogenic RNA aptamer, Published online: 15 April 2019; doi:10.1038/s41589-019-0267-9
Structural analysis of Mango-III in complex with fluorophores reveals a globular architecture and a planar conformation of fluorophores. Structure-guided mutation and functional reselection identified two mutants with improved fluorescence intensity.Chemogenetics defines receptor-mediated functions of short chain free fatty acids
April 15th, 2019 by Daniele Bolognini
Chemogenetics defines receptor-mediated functions of short chain free fatty acids
Chemogenetics defines receptor-mediated functions of short chain free fatty acids, Published online: 15 April 2019; doi:10.1038/s41589-019-0270-1
A chemogenomic approach to explore activity of the free fatty acid receptor FFA2 independently of the related FFA3 shows that FFA2 in differentiated adipocytes and colonic crypt cells in mice is responsible for regulated lipolysis and GLP-1 release.