Understanding the Pro/N-end rule pathway
April 16th, 2018 by David A. Dougan
Understanding the Pro/N-end rule pathway
Understanding the Pro/N-end rule pathway, Published online: 16 April 2018; doi:10.1038/s41589-018-0045-0
Regulated destruction of proteins underlies just about everything a cell does. A structural study of human Gid4, the N-recognin of the Pro/N-end rule pathway that targets proteins through their N-terminal proline, illuminates the recognition of substrates by this proteolytic system.Designing macrocyclic disulfide-rich peptides for biotechnological applications
April 16th, 2018 by Conan K. Wang
Designing macrocyclic disulfide-rich peptides for biotechnological applications
Designing macrocyclic disulfide-rich peptides for biotechnological applications, Published online: 16 April 2018; doi:10.1038/s41589-018-0039-y
Through molecular grafting, cyclic disulfide-rich peptides can be used as scaffolds to improve the stability, rigidity, and cellular uptake of bioactive peptides, although a number of factors should be considered when designing such grafted peptides.Dynamic coupling between conformations and nucleotide states in DNA gyrase
April 16th, 2018 by Aakash Basu
Dynamic coupling between conformations and nucleotide states in DNA gyrase
Dynamic coupling between conformations and nucleotide states in DNA gyrase, Published online: 16 April 2018; doi:10.1038/s41589-018-0037-0
Single-molecule measurements of DNA gyrase activity reveal conformational dynamics coupling ATP consumption to DNA supercoiling.Structure in sequence
April 16th, 2018 by Yiyun Song
Structure in sequence
Structure in sequence, Published online: 16 April 2018; doi:10.1038/s41589-018-0050-3
Structure in sequenceThe peptide <span class=”small-caps”>d</span>-list
April 16th, 2018 by Mirella Bucci
The peptide d-list
The peptide <span class="small-caps">d</span>-list, Published online: 16 April 2018; doi:10.1038/s41589-018-0049-9
The peptide d-listFueled by light
April 16th, 2018 by Grant Miura
Fueled by light
Fueled by light, Published online: 16 April 2018; doi:10.1038/s41589-018-0048-x
Fueled by lightGenome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic
April 16th, 2018 by Marina Santiago
Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic
Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic, Published online: 16 April 2018; doi:10.1038/s41589-018-0041-4
Use of a combined Tn-seq and machine-learning approach for predicting mechanisms and targets of antibiotic action in Staphylococcus aureus shows that the natural product lysocin E (LysE) binds Lipid II on the cell surface and damages the membrane.Spotting the signal
April 16th, 2018 by Caitlin Deane
Spotting the signal
Spotting the signal, Published online: 16 April 2018; doi:10.1038/s41589-018-0047-y
Spotting the signal[ASAP] Second-Shell Hydrogen Bond Impacts Transition-State Structure in <italic toggle=”yes”>Bacillus subtilis</italic> Oxalate Decarboxylase
April 11th, 2018 by Wen Zhu, Laurie A. Reinhardt, Nigel G. J. Richards
Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes
April 2nd, 2018 by Simon Wisnovsky
Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes
Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes, Published online: 02 April 2018; doi:10.1038/s41589-018-0040-5
Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes