[ASAP] Structural Basis for the Interactions of the Colibactin Resistance Gene Product ClbS with DNA

May 3rd, 2021 by Prabhanshu Tripathi and Steven D. Bruner

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Biochemistry
DOI: 10.1021/acs.biochem.1c00201

A molecular trap inside microtubules probes luminal access by soluble proteins

May 3rd, 2021 by Yuta Nihongaki

Nature Chemical Biology, Published online: 03 May 2021; doi:10.1038/s41589-021-00791-w

A chemically inducible technique for trapping cytosolic proteins in microtubules (MTs) in cells reveals that soluble proteins can enter the MT lumen by diffusion, while proteins forming a complex with tubulins can be incorporated at MT plus ends.
  • Posted in Nat Chem Biol, Publications
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[ASAP] The Autocatalytic Cleavage Domain Is Not Required for the Activity of ScpC, a Virulence Protease from <italic toggle=”yes”>Streptococcus pyogenes</italic>: A Structural Insight

April 29th, 2021 by Chacko Jobichen, Tan Ying Chong, Tai Hui Ling, and J. Sivaraman

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Biochemistry
DOI: 10.1021/acs.biochem.1c00185

ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

April 29th, 2021 by Jarrett R. Remsberg

Nature Chemical Biology, Published online: 29 April 2021; doi:10.1038/s41589-021-00785-8

ABD957 is a potent and selective inhibitor of the ABHD17 family of depalmitoylases that disrupts N-Ras signaling in human acute myeloid leukemia cells and can synergize with MEK inhibition.
  • Posted in Nat Chem Biol, Publications
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A stop sign for RAS trafficking

April 29th, 2021 by Tian Qiu

Nature Chemical Biology, Published online: 29 April 2021; doi:10.1038/s41589-021-00789-4

N-Ras lipidation cycling is known to regulate its trafficking and function. A new S-depalmitoylation inhibitor induces N-Ras membrane mislocalization, providing insights into N-Ras function and laying the foundation for a new cancer therapeutic strategy.

[ASAP] Engineered Microbial Routes for Human Milk Oligosaccharides Synthesis

April 27th, 2021 by Mengyao Lu, Imann Mosleh, and Alireza Abbaspourrad

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.1c00063

Engineering AraC to make it responsive to light instead of arabinose

April 26th, 2021 by Edoardo Romano

Nature Chemical Biology, Published online: 26 April 2021; doi:10.1038/s41589-021-00787-6

Engineering of a blue light-inducible AraC dimerization system in E. coli permits light-dependent, rather than arabinose-based, regulation of gene expression from standard PBAD promoters, enabling temporal and spatial control of bacterial systems.

Focal assembly

April 26th, 2021 by Yiyun Song

Nature Chemical Biology, Published online: 26 April 2021; doi:10.1038/s41589-021-00797-4

Focal assembly

Guiding light

April 26th, 2021 by Grant Miura

Nature Chemical Biology, Published online: 26 April 2021; doi:10.1038/s41589-021-00794-7

Guiding light

Designing stable DNAzymes

April 26th, 2021 by Ross Cloney

Nature Chemical Biology, Published online: 26 April 2021; doi:10.1038/s41589-021-00796-5

Designing stable DNAzymes