[ASAP] Transferrin Cycle and Clinical Roles of Citrate and Ascorbate in Improved Iron Metabolism

April 23rd, 2019 by Aviva Levina, Peter A. Lay

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.8b01100

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

April 22nd, 2019 by Wim Dejonghe

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function, Published online: 22 April 2019; doi:10.1038/s41589-019-0262-1

Affinity-based target isolation and X-ray crystallography enabled identification of the non-protonophore ES9-17 as an inhibitor of the clathrin heavy chain in plants, enabling disruption of endocytosis.
  • Posted in Nat Chem Biol, Publications
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Braking plant endocytosis

April 22nd, 2019 by Chunhua Zhang

Braking plant endocytosis

Braking plant endocytosis, Published online: 22 April 2019; doi:10.1038/s41589-019-0273-y

Endocytosis mediates the internalization of proteins and lipids at the plasma membrane and plays essential roles in plant growth and development. A new small molecule enables manipulation of plant endocytosis in an acute and transient manner.

Marking histones

April 16th, 2019 by Yiyun Song

Marking histones

Marking histones, Published online: 16 April 2019; doi:10.1038/s41589-019-0283-9

Marking histones

Cannabinoids on the rise

April 16th, 2019 by Caitlin Deane

Cannabinoids on the rise

Cannabinoids on the rise, Published online: 16 April 2019; doi:10.1038/s41589-019-0280-z

Cannabinoids on the rise

Scaffold and organism hopping with chemical probes

April 16th, 2019 by Jürg Gertsch

Scaffold and organism hopping with chemical probes

Scaffold and organism hopping with chemical probes, Published online: 16 April 2019; doi:10.1038/s41589-019-0275-9

Chemical probes that irreversibly inhibit protein function may be used across species to discover proteins. Combining phenotypic screening and activity-based protein profiling, a new study uncovers a discrete lipid signaling pathway regulating lifespan in the worm Caenorhabditis elegans.

Under pressure

April 16th, 2019 by Grant Miura

Under pressure

Under pressure, Published online: 16 April 2019; doi:10.1038/s41589-019-0282-x

Under pressure

Avoiding the dumpster

April 16th, 2019 by Grant Miura

Avoiding the dumpster

Avoiding the dumpster, Published online: 16 April 2019; doi:10.1038/s41589-019-0281-y

Avoiding the dumpster

Structure and functional reselection of the Mango-III fluorogenic RNA aptamer

April 15th, 2019 by Robert J. Trachman III

Structure and functional reselection of the Mango-III fluorogenic RNA aptamer

Structure and functional reselection of the Mango-III fluorogenic RNA aptamer, Published online: 15 April 2019; doi:10.1038/s41589-019-0267-9

Structural analysis of Mango-III in complex with fluorophores reveals a globular architecture and a planar conformation of fluorophores. Structure-guided mutation and functional reselection identified two mutants with improved fluorescence intensity.
  • Posted in Nat Chem Biol, Publications
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Chemogenetics defines receptor-mediated functions of short chain free fatty acids

April 15th, 2019 by Daniele Bolognini

Chemogenetics defines receptor-mediated functions of short chain free fatty acids

Chemogenetics defines receptor-mediated functions of short chain free fatty acids, Published online: 15 April 2019; doi:10.1038/s41589-019-0270-1

A chemogenomic approach to explore activity of the free fatty acid receptor FFA2 independently of the related FFA3 shows that FFA2 in differentiated adipocytes and colonic crypt cells in mice is responsible for regulated lipolysis and GLP-1 release.
  • Posted in Nat Chem Biol, Publications
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