[ASAP] Nucleosome Dynamics during Transcription Elongation

December 2nd, 2020 by Mai T. Huynh, Satya P. Yadav, Joseph C. Reese, and Tae-Hee Lee

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ACS Chemical Biology
DOI: 10.1021/acschembio.0c00617

[ASAP] In Vitro Hydrolysis of Zinc Chlorophyllide <italic toggle=”yes”>a</italic> Homologues by a BciC Enzyme

December 1st, 2020 by Mitsuaki Hirose, Jiro Harada, and Hitoshi Tamiaki

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Biochemistry
DOI: 10.1021/acs.biochem.0c00850

Cryptic phosphorylation in nucleoside natural product biosynthesis

November 30th, 2020 by Matthew M. Draelos

Nature Chemical Biology, Published online: 30 November 2020; doi:10.1038/s41589-020-00656-8

Rather than their expected role in self-immunity, kinases encoded in the biosynthetic gene clusters of nucleoside natural products catalyze the phosphorylation of an early intermediate, a modification that is later removed in a downstream step.

[ASAP] Living Therapeutics: The Next Frontier of Precision Medicine

November 18th, 2020 by Vince W. Kelly, Benjamin K. Liang, and Shannon J. Sirk

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00444

[ASAP] Correction to “Hepatocellular Carcinoma and Statins”

November 17th, 2020 by Ghazal Alipour Talesh, Véronique Trézéguet, and Aksam Merched

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Biochemistry
DOI: 10.1021/acs.biochem.0c00868

Making use of surplus sugar

November 16th, 2020 by Niels Agerbirk

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00687-1

Insects have many ways of disabling plant chemical defenses during feeding. Plant phloem feeders use surplus ingested sugar to block the activation of glucosinolate toxins, providing a target for precise resistance breeding.

Delimiting lipids

November 16th, 2020 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00701-6

This themed issue features a collection of articles that explore long-standing questions in the study of lipids and membranes.

The conformational cycle of a prototypical voltage-gated sodium channel

November 16th, 2020 by William A. Catterall

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-0644-4

The conformational cycle of a bacterial voltage-gated sodium channel as it transitions from resting to activated open to inactivated closed states can be constructed from various crystal structure snapshots.
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

November 16th, 2020 by James Schiemer

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00686-2

The authors report PROTAC ternary complex structures involving the E3 ligase cIAP1 and target protein BTK, showing that cooperativity is not always correlated with degradation efficiency.
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Defining new chemical space for drug penetration into Gram-negative bacteria

November 16th, 2020 by Shibin Zhao

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00674-6

The difficulty of antibiotic discovery posed by the double-membrane cell envelope of Gram-negative bacteria and active drug efflux requires better understanding of bacterial permeability and compound accumulation, and more diverse chemical libraries.
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