Structural basis of sequence-specific Holliday junction cleavage by MOC1

October 14th, 2019 by Huajian Lin

Nature Chemical Biology, Published online: 14 October 2019; doi:10.1038/s41589-019-0377-4

Crystal structural and biochemical analysis of the chloroplast-localized Holliday junction (HJ) resolvase MOC1 in Zea mays reveals that ZmMOC1 uses a unique β-hairpin structure and a two-metal ion catalysis mechanism to recognize and cleave HJs.
  • Posted in Nat Chem Biol, Publications
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Long-range tedatmporal coordination of gene expression in synthetic microbial consortia

October 14th, 2019 by Jae Kyoung Kim

Nature Chemical Biology, Published online: 14 October 2019; doi:10.1038/s41589-019-0372-9

Synthetic microbial consortia were applied to demonstrate that oscillatory gene expression in a bacterial population can be propagated over longer distances by activating a localized positive feedback loop.
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[ASAP] The Expanding Role of Methyl-Coenzyme M Reductase in the Anaerobic Functionalization of Alkanes

October 10th, 2019 by Danielle V. Miller† and Squire J. Booker*†‡§

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Biochemistry
DOI: 10.1021/acs.biochem.9b00859

A lipid site shapes the agonist response of a pentameric ligand-gated ion channel

October 7th, 2019 by Camille M. Hénault

Nature Chemical Biology, Published online: 07 October 2019; doi:10.1038/s41589-019-0369-4

A crystal structure of prokaryotic pentameric ligand-gated ion channel ELIC reveals a lipid-binding site at the interface between subunits that is shaped by a flexible helix important for channel desensitization upon lipid binding.
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A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

October 7th, 2019 by Mark F. van Delft

Nature Chemical Biology, Published online: 07 October 2019; doi:10.1038/s41589-019-0365-8

A phenotypic screen led to the identification of potent inhibitors of mouse BAK-driven apoptosis. The compounds interact with VDAC2 and stabilize its interaction with BAK, blocking apoptosis at an early stage to preserve long-term cell survival.
  • Posted in Nat Chem Biol, Publications
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Axonal iron transport in the brain modulates anxiety-related behaviors

October 7th, 2019 by Zhuo Wang

Nature Chemical Biology, Published online: 07 October 2019; doi:10.1038/s41589-019-0371-x

Iron is transported from the ventral hippocampus to the medial prefrontal cortex unidirectionally in the brain via axonal projections. This transport is involved in mediating anxiety and the anxiolytic effects of diazepam.
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Mapping spatial transcriptome with light-activated proximity-dependent RNA labeling

October 7th, 2019 by Pengchong Wang

Nature Chemical Biology, Published online: 07 October 2019; doi:10.1038/s41589-019-0368-5

A light-activated RNA labeling method was developed to determine spatial organization of a transcriptome and found that ribosomal proteins and oxidative phosphorylation pathway proteins are highly enriched at the outer mitochondrial membrane.
  • Posted in Nat Chem Biol, Publications
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p63 is a cereblon substrate involved in thalidomide teratogenicity

October 7th, 2019 by Tomoko Asatsuma-Okumura

Nature Chemical Biology, Published online: 07 October 2019; doi:10.1038/s41589-019-0366-7

Zebrafish p63 isoforms were identified as thalidomide-dependent neosubstrates of the cereblon-containing E3 ligase complex. ∆Np63α and TAp63α are responsible for thalidomide-induced malformations of pectoral fins and otic vesicles, respectively.

[ASAP] Not All Quiet on the Sugar Front: Glycan Combatants in Host–Pathogen Interactions

October 6th, 2019 by Atossa C. Ghorashi and Jennifer J. Kohler*

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Biochemistry
DOI: 10.1021/acs.biochem.9b00524

[ASAP] Proteolytic Control of Lipid Metabolism

September 29th, 2019 by Pingdewinde N. Sam†, Erica Avery†, and Steven M. Claypool*

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ACS Chemical Biology
DOI: 10.1021/acschembio.9b00695