Mutanofactin promotes adhesion and biofilm formation of cariogenic <i>Streptococcus mutans</i>
March 4th, 2021 by Zhong-Rui Li
Nature Chemical Biology, Published online: 04 March 2021; doi:10.1038/s41589-021-00745-2
The mutanofactin family of lipopeptide natural products, produced by strains of cariogenic Streptococcus mutans, promotes biofilm formation via increased cell-surface hydrophobicity and binding to extracellular DNA.Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy
March 4th, 2021 by Liguo Wang
Nature Chemical Biology, Published online: 04 March 2021; doi:10.1038/s41589-021-00742-5
A selective and potent CDK2 degrader was developed that induced differentiation of acute myeloid leukemia cell lines and primary patient cells.Author Correction: Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
March 2nd, 2021 by Yilong Zou
Nature Chemical Biology, Published online: 02 March 2021; doi:10.1038/s41589-021-00767-w
Author Correction: Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosisOrphan receptor GPR37L1 remains unliganded
March 1st, 2021 by Tony Ngo
Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00748-z
Orphan receptor GPR37L1 remains unligandedBinding site for activator MDL-801 on SIRT6
March 1st, 2021 by Weijie You
Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00749-y
Binding site for activator MDL-801 on SIRT6Reply to: Binding site for MDL-801 on SIRT6
March 1st, 2021 by Zhimin Huang
Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00750-5
Reply to: Binding site for MDL-801 on SIRT6Oncohistones: corruption at the core
March 1st, 2021 by Kanishk Jain
Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00764-z
High-throughput biochemical and biological analyses of disease-associated histone mutations reveal key residues in globular cores that affect chromatin remodeling, nucleosome stability, and stem cell pluripotency.Retraction Note: Orphan receptor ligand discovery by pickpocketing pharmacological neighbors
March 1st, 2021 by Tony Ngo
Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00746-1
Retraction Note: Orphan receptor ligand discovery by pickpocketing pharmacological neighbors[ASAP] Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin
March 1st, 2021 by James A. Ferguson, Xun Sun, H. Jane Dyson, and Peter E. Wright
ROS regulated reversible protein phase separation synchronizes plant flowering
February 25th, 2021 by Xiaozhen Huang
Nature Chemical Biology, Published online: 25 February 2021; doi:10.1038/s41589-021-00739-0
Plants utilize naturally produced ROS in shoot apical stem cells as a developmental signal to trigger phase separation of TMF. The resulting transcriptional condensates repress expression of the floral identity gene to precisely time flowering.