[ASAP] Nucleosome Dynamics during Transcription Elongation
December 2nd, 2020 by Mai T. Huynh, Satya P. Yadav, Joseph C. Reese, and Tae-Hee Lee
[ASAP] In Vitro Hydrolysis of Zinc Chlorophyllide <italic toggle=”yes”>a</italic> Homologues by a BciC Enzyme
December 1st, 2020 by Mitsuaki Hirose, Jiro Harada, and Hitoshi Tamiaki
Cryptic phosphorylation in nucleoside natural product biosynthesis
November 30th, 2020 by Matthew M. Draelos
Nature Chemical Biology, Published online: 30 November 2020; doi:10.1038/s41589-020-00656-8
Rather than their expected role in self-immunity, kinases encoded in the biosynthetic gene clusters of nucleoside natural products catalyze the phosphorylation of an early intermediate, a modification that is later removed in a downstream step.[ASAP] Living Therapeutics: The Next Frontier of Precision Medicine
November 18th, 2020 by Vince W. Kelly, Benjamin K. Liang, and Shannon J. Sirk
[ASAP] Correction to “Hepatocellular Carcinoma and Statins”
November 17th, 2020 by Ghazal Alipour Talesh, Véronique Trézéguet, and Aksam Merched
Making use of surplus sugar
November 16th, 2020 by Niels Agerbirk
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00687-1
Insects have many ways of disabling plant chemical defenses during feeding. Plant phloem feeders use surplus ingested sugar to block the activation of glucosinolate toxins, providing a target for precise resistance breeding.Delimiting lipids
November 16th, 2020 by Nature Chemical Biology - Issue - nature.com science feeds
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00701-6
This themed issue features a collection of articles that explore long-standing questions in the study of lipids and membranes.The conformational cycle of a prototypical voltage-gated sodium channel
November 16th, 2020 by William A. Catterall
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-0644-4
The conformational cycle of a bacterial voltage-gated sodium channel as it transitions from resting to activated open to inactivated closed states can be constructed from various crystal structure snapshots.Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
November 16th, 2020 by James Schiemer
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00686-2
The authors report PROTAC ternary complex structures involving the E3 ligase cIAP1 and target protein BTK, showing that cooperativity is not always correlated with degradation efficiency.Defining new chemical space for drug penetration into Gram-negative bacteria
November 16th, 2020 by Shibin Zhao
Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00674-6
The difficulty of antibiotic discovery posed by the double-membrane cell envelope of Gram-negative bacteria and active drug efflux requires better understanding of bacterial permeability and compound accumulation, and more diverse chemical libraries.