Ubiquitin-proteasome system: Rescuing EBV latency
August 18th, 2017 by Mirella Bucci
Nature Chemical Biology 13, 923 (2017). doi:10.1038/nchembio.2466
Author: Mirella Bucci
A kinetic view of GPCR allostery and biased agonism
August 18th, 2017 by J Robert Lane
Nature Chemical Biology 13, 929 (2017). doi:10.1038/nchembio.2431
Authors: J Robert Lane, Lauren T May, Robert G Parton, Patrick M Sexton & Arthur Christopoulos
Drug development: Locking down metabolism
August 18th, 2017 by William R Bishai
Nature Chemical Biology 13, 925 (2017). doi:10.1038/nchembio.2452
Author: William R Bishai
An allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase—an enzyme that is nonessential for in vitro growth—has potent antimicrobial activity, revealing a potentially expanded target list for antimicrobials and greater chemical space for new inhibitors.
Bacterial immunity: A virtuous CRISPR cycle
August 18th, 2017 by Terry L. Sheppard
Nature Chemical Biology 13, 923 (2017). doi:10.1038/nchembio.2468
Author: Terry L. Sheppard
Neurobiology: Lighting up neurons
August 18th, 2017 by Grant Miura
Nature Chemical Biology 13, 923 (2017). doi:10.1038/nchembio.2469
Author: Grant Miura
Protein design: I like to fold it, fold it
August 18th, 2017 by Caitlin Deane
Nature Chemical Biology 13, 923 (2017). doi:10.1038/nchembio.2467
Author: Caitlin Deane
Extracellular vesicles: Taking metabolism on the road
August 18th, 2017 by Lucas B Sullivan
Nature Chemical Biology 13, 924 (2017). doi:10.1038/nchembio.2455
Author: Lucas B Sullivan
Extracellular vesicles (EVs) are a class of secreted membrane particles capable of transferring biological molecules between cells. Metabolomics measurements indicate that isolated EVs also have autonomous metabolic enzyme activities, including the unexpected identification of endogenous human asparaginase activity.
Protein engineering: Redirecting membrane machinery
August 18th, 2017 by Kalistyn Burley
Nature Chemical Biology 13, 927 (2017). doi:10.1038/nchembio.2451
Authors: Kalistyn Burley & Celia W Goulding
The ability to solubilize membrane proteins while retaining their native function is a persistent challenge. Re-engineering of the membrane protein DsbB into a soluble cytoplasmic version maintained its activity and enabled recompartmentalization of the periplasmic DsbAB disulfide bond–forming system.
Lysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates
August 16th, 2017 by Tasha B. Toro, Jenae R. Bryant and Terry J. Watt
Functional Complementation Studies Reveal Different Interaction Partners of Escherichia coli IscS and Human NFS1
August 16th, 2017 by Martin Bühning, Martin Friemel and Silke Leimkühler
