Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites
October 18th, 2017 by Jack G. Ganley, Maria Toro-Moreno and Emily R. Derbyshire
Hop to It
October 13th, 2017 by Jillian L. Dempsey and Matthew R. Hartings
Fluorotryptophan Incorporation Modulates the Structure and Stability of Transthyretin in a Site-Specific Manner
September 28th, 2017 by Xun Sun, H. Jane Dyson and Peter E. Wright
Transfer Hydrogenation Catalyzed by Organometallic Complexes Using NADH as a Reductant in a Biochemical Context
September 27th, 2017 by Yasunori Okamoto and Thomas R. Ward
Cation−π Lights Up “Halo”
September 20th, 2017 by Jianmin Gao
Erratum: A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation
September 19th, 2017 by Kai Papenfort
Nature Chemical Biology 13, 1137 (2017). doi:10.1038/nchembio1017-1137b
Author: Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost & Bonnie L Bassler
Corrigendum: Parallel evolution of non-homologous isofunctional enzymes in methionine biosynthesis
September 19th, 2017 by Karine Bastard
Nature Chemical Biology 13, 1137 (2017). doi:10.1038/nchembio1017-1137c
Author: Karine Bastard, Alain Perret, Aline Mariage, Thomas Bessonnet, Agnès Pinet-Turpault, Jean-Louis Petit, Ekaterina Darii, Pascal Bazire, Carine Vergne-Vaxelaire, Clémence Brewee, Adrien Debard, Virginie Pellouin, Marielle Besnard-Gonnet, François Artiguenave, Claudine Médigue, David Vallenet, Antoine Danchin, Anne Zaparucha, Jean Weissenbach, Marcel Salanoubat & Véronique de Berardinis
Erratum: A Vibrio cholerae autoinducer–receptor pair that controls biofilm formation
September 19th, 2017 by Kai Papenfort
Nature Chemical Biology 13, 1137 (2017). doi:10.1038/nchembio1017-1137a
Author: Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost & Bonnie L Bassler
Biosynthesis: SAM cycles up for colibactin
September 19th, 2017 by Steven G Van Lanen
Nature Chemical Biology 13, 1059 (2017). doi:10.1038/nchembio.2479
Author: Steven G Van Lanen
The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.
Genome mining: Digging the tunnel for chemical space
September 19th, 2017 by Ha An Nguyen
Nature Chemical Biology 13, 1061 (2017). doi:10.1038/nchembio.2480
Authors: Ha An Nguyen & Christine M Dunham
Genome mining reveals a new ribosomally synthesized and post-translationally modified peptide (RiPP) from Klebsiella pneumoniae. This new antibiotic inhibits bacterial ribosomes by obstructing the peptide exit tunnel, and its modular nature presents a unique opportunity for future engineering of antibacterial drugs.