[ASAP] Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells
December 12th, 2018 by Brodie L. Ranzau, Alexis C. Komor
[ASAP] The Polycystin Complex Reveals Its Complexity
December 12th, 2018 by Valeria Padovano, Michael J. Caplan
Lanthanide lover
December 10th, 2018 by Caitlin Deane
Lanthanide lover
Lanthanide lover, Published online: 10 December 2018; doi:10.1038/s41589-018-0196-z
Lanthanide loverDesign of fast proteolysis-based signaling and logic circuits in mammalian cells
December 10th, 2018 by Tina Fink
Design of fast proteolysis-based signaling and logic circuits in mammalian cells
Design of fast proteolysis-based signaling and logic circuits in mammalian cells, Published online: 10 December 2018; doi:10.1038/s41589-018-0181-6
Protease-cleavable orthogonal-coiled-coil-based (SPOC) systems, in which split viral proteases are activated by small molecules and cleave coiled-coil protease substrates, reprogram signaling with rapid kinetics in mammalian cells.<i>N</i><sup>6-</sup>Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
December 10th, 2018 by Honghui Ma
N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
<i>N</i><sup>6-</sup>Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation, Published online: 10 December 2018; doi:10.1038/s41589-018-0184-3
ZCCHC4 was identified as a mammalian ribosome RNA (rRNA) N6-methyladenosine (m6A) writer protein that installs m6A 4220 in 28S rRNA. 28S rRNA methylation affects global translation and cell growth and contributes to tumorigenesis in cancer cells.The bacteria that move me
December 10th, 2018 by Mirella Bucci
The bacteria that move me
The bacteria that move me, Published online: 10 December 2018; doi:10.1038/s41589-018-0198-x
The bacteria that move meRiboregulated toehold-gated gRNA for programmable CRISPR–Cas9 function
December 10th, 2018 by Ka-Hei Siu
Riboregulated toehold-gated gRNA for programmable CRISPR–Cas9 function
Riboregulated toehold-gated gRNA for programmable CRISPR–Cas9 function, Published online: 10 December 2018; doi:10.1038/s41589-018-0186-1
Engineering of toehold-gated guide RNA (thgRNA) by tethering toehold riboswitches to sgRNAs enables the activation of CRISPR–Cas9 genome editing or transcriptional regulation in response to complementary synthetic or endogenous cellular RNAs.<i>N</i><sup>6</sup>-mA condenses chromatin
December 10th, 2018 by Yiyun Song
N6-mA condenses chromatin
<i>N</i><sup>6</sup>-mA condenses chromatin, Published online: 10 December 2018; doi:10.1038/s41589-018-0199-9
N6-mA condenses chromatinMechanistic insights revealed by a UBE2A mutation linked to intellectual disability
December 10th, 2018 by Juliana Ferreira de Oliveira
Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability
Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability, Published online: 10 December 2018; doi:10.1038/s41589-018-0177-2
Structural and biochemical analysis of a UBE2A mutation linked to intellectual disability reveals that the Q93E mutant perturbs the E2 catalytic microenvironment essential for lysine deprotonation during the ubiquitin-transfer process.E2 enzymes: lessons in ubiquitin transfer from XLID patients
December 10th, 2018 by Martina Foglizzo
E2 enzymes: lessons in ubiquitin transfer from XLID patients
E2 enzymes: lessons in ubiquitin transfer from XLID patients, Published online: 10 December 2018; doi:10.1038/s41589-018-0191-4
Characterization of a novel mutation in the E2 ubiquitin-conjugating enzyme UBE2A accounts for the decreased activity of the mutant enzyme that underlies disease and provides important insight into the catalytic mechanism of E2s.