Voices of chemical biology

May 22nd, 2020 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology, Published online: 22 May 2020; doi:10.1038/s41589-020-0543-8

We asked a collection of chemical biologists, “What was the most exciting research achievement or technology innovation in chemical biology in the last five years?” and reveal some of the perspectives we received.

Greatest hits

May 22nd, 2020 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology, Published online: 22 May 2020; doi:10.1038/s41589-020-0546-5

We present a selection of papers published in Nature Chemical Biology over the past five years that reflect the diversity and excitement of chemical biology research.

15 years of <i>Nature Chemical Biology</i>

May 22nd, 2020 by Nature Chemical Biology - Issue - nature.com science feeds

Nature Chemical Biology, Published online: 22 May 2020; doi:10.1038/s41589-020-0560-7

Over the past decade and a half, chemical biology has crystallized as a discipline and extended its reach into new scientific areas, but the field’s greatest promise lies ahead.

Chromatin as a key consumer in the metabolite economy

May 22nd, 2020 by Katharine L. Diehl

Nature Chemical Biology, Published online: 22 May 2020; doi:10.1038/s41589-020-0517-x

This Perspective highlights emerging themes in the inter-regulation of the genome and metabolism via chromatin, including nonenzymatic histone modifications, cofactor-promiscuous chromatin-modifying enzymes, and subnucleocytoplasmic metabolite pools.

A tail of CRY selectivity

May 22nd, 2020 by Julia Lara

Nature Chemical Biology, Published online: 22 May 2020; doi:10.1038/s41589-020-0531-z

The discovery of selective modulators of two Cryptochrome isoforms, CRY1 and CRY2, permits a deeper understanding of how circadian clock proteins impact diverse aspects of our daily 24-h rhythms and how this intersects with metabolic pathways relevant to disease.

Yes (again) to local NO

May 22nd, 2020 by Emrah Eroglu

Nature Chemical Biology, Published online: 22 May 2020; doi:10.1038/s41589-020-0552-7

A pair of fluorescent indicator-tagged DNA-duplex scaffolds permit assessments of nitric oxide (NO) production on cell surfaces and in intracellular networks. The application of these nanoprobes indicates formations of local NO signals that might conserve cancer cell integrity.

The developing toolkit of continuous directed evolution

May 22nd, 2020 by Mary S. Morrison

Nature Chemical Biology, Published online: 22 May 2020; doi:10.1038/s41589-020-0532-y

This historical Perspective on continuous directed evolution focuses on laboratory approaches that enable greater understanding of evolving molecular populations and offer investigators tools to guide the emergence of new biomolecular systems.

[ASAP] CRISPRi-dCas12a: A dCas12a-Mediated CRISPR Interference for Repression of Multiple Genes and Metabolic Engineering in Cyanobacteria

May 18th, 2020 by Sun Young Choi†‡ and Han Min Woo*†‡

TOC Graphic

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00091
  • Posted in ACS Synthetic Biology, Publications
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Design of orthogonal regulatory systems for modulating gene expression in plants

May 18th, 2020 by Michael S. Belcher

Nature Chemical Biology, Published online: 18 May 2020; doi:10.1038/s41589-020-0547-4

Engineering of yeast transcription factors and design of hybrid DNA promoter elements have resulted in a toolkit for tunable and orthogonal regulation of gene expression in Arabidopsis thaliana and Nicotiana benthamiana plants.
  • Posted in Nat Chem Biol, Publications
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Spring 2020 Newsletter Released!

May 17th, 2020 by pthomas2

The Spring 2020 newsletter was just released. BIOL members should have received it in their email. You can find the newsletter here.

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