For outstanding research in biological chemistry of unusual merit and independence of thought and originality.
We are pleased to select Professor Lingyin Li for the 2022 Eli Lilly Award in Biological Chemistry. This award is being bestowed based on Professor Li’s substantial and significant contributions to discovering the molecular basis for innate immune activation through the STING pathway. Professor Li received her Ph.D. at the University of Wisconsin with Professor Laura Kiessling and then performed postdoctoral studies with Professor Timothy Mitchison at Harvard Medical School. Professor Li established her independent research program at Stanford University in 2015. The Li laboratory has pioneered the development of chemical tools to define and manipulate new modulators of the STING pathway. Using this interdisciplinary, problem-driven approach, the Li lab has developed significant insights into how STING senses cyclic dinucleotides, how immune metabolites are processed and transported by the cell, and how small molecules may be leveraged to agonize or antagonize these mechanisms. These advances have significant implications for our understanding of disease and immune-based therapies. In the course of these studies, Professor Li has published significant papers in leading journals (Cell, Nature Cancer, Molecular Cell, Cell Chemical Biology, ACS Central Science), mentored several excellent trainees, and been honored by other awards (C&E News Talented 12 and an NIH Director’s New Innovator Award). Professor Li is a highly deserving recipient of the 2022 Eli Lilly Award in Biological Chemistry.