Professor Thomas L. Poulos will present the 2014 Gordon Hammes ACS Biochemistry Lecture at the Fall 2014 National Meeting of the American Chemical Society in recognition of his research achievements on the structural biology of heme enzymes. Poulos’ research focuses on the structural biology of heme enzymes. He solved the first heme enzyme crystal structure, cytochrome c peroxidase, and the first cytochrome P450 crystal structure. Since then he and his coworkers have solved the structure of other metallo-enzymes and related electron transfer proteins including nitric oxide synthase (NOS). These structures coupled with protein engineering, enzymological, and spectroscopic approaches have sought to elucidate how these enzymes activate peroxide and molecular oxygen, a required step in many substrate oxidation reactions. A related area is the structure of redox protein complexes and how redox partner recognition is coupled to functionally important structural changes. In collaboration with Prof. Rick Silverman (Northwestern), the Poulos group also is working in the area of NOS structure-based drug design in an effort to develop therapeutic agents for neurodegenerative diseases.