Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

August 22nd, 2016 by Zhong-Rui Li

Nature Chemical Biology 12, 773 (2016). doi:10.1038/nchembio.2157

Authors: Zhong-Rui Li, Jie Li, Jin-Ping Gu, Jennifer Y H Lai, Brendan M Duggan, Wei-Peng Zhang, Zhi-Long Li, Yong-Xin Li, Rong-Biao Tong, Ying Xu, Dong-Hai Lin, Bradley S Moore & Pei-Yuan Qian

Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical.

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