Identification of a cellularly active SIRT6 allosteric activator

October 29th, 2018 by Zhimin Huang

Identification of a cellularly active SIRT6 allosteric activator

Identification of a cellularly active SIRT6 allosteric activator, Published online: 29 October 2018; doi:10.1038/s41589-018-0150-0

The use of an allosteric drug-design method resulted in the identification of a first-in-class cellularly active SIRT6 activator that induces cell-cycle arrest in the G0–G1 phase, thus suppressing proliferation in human hepatocellular carcinoma cells.