Site-specific acylation of a bacterial virulence regulator attenuates infection

November 18th, 2019 by Zhenrun J. Zhang

Nature Chemical Biology, Published online: 18 November 2019; doi:10.1038/s41589-019-0392-5

Microbiota-derived butyrate acylation of the key Salmonella enterica transcriptional regulator HilA attenuates virulence of the bacteria, blocking invasion of epithelial cells in vitro and dissemination in vivo.
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