Pyridoxal-5′-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis

June 1st, 2020 by Zheng Cui

Nature Chemical Biology, Published online: 01 June 2020; doi:10.1038/s41589-020-0548-3

Rather than a typical S-adenosylmethionine-dependent alkyltransferase, the installation of the N-alkylamine linker in several nucleoside antibiotics is catalyzed via γ-replacement by a pyridoxal-5′-phosphate-dependent aminobutyryltransferase.
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