A split CRISPR–Cpf1 platform for inducible genome editing and gene activation

August 12th, 2019 by Yuta Nihongaki

Nature Chemical Biology, Published online: 12 August 2019; doi:10.1038/s41589-019-0338-y

Split Cpf1 pairs are identified to enable chemical- and light-induced genome editing via dimerization. Another pair of split Cpf1 can be used to activate gene expression with high efficiency in cells and in mice.
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