A split CRISPR–Cpf1 platform for inducible genome editing and gene activation
August 12th, 2019 by Yuta Nihongaki
Nature Chemical Biology, Published online: 12 August 2019; doi:10.1038/s41589-019-0338-y
Split Cpf1 pairs are identified to enable chemical- and light-induced genome editing via dimerization. Another pair of split Cpf1 can be used to activate gene expression with high efficiency in cells and in mice.