Structural basis of 7SK RNA 5′-γ-phosphate methylation and retention by MePCE

December 17th, 2018 by Yuan Yang

Structural basis of 7SK RNA 5′-γ-phosphate methylation and retention by MePCE

Structural basis of 7SK RNA 5′-γ-phosphate methylation and retention by MePCE, Published online: 17 December 2018; doi:10.1038/s41589-018-0188-z

Structural analysis of the human MePCE methyltransferase domain in complex with 7SK in the presence of SAH or SAM reveals that MePCE has higher affinity for capped 7SK and holds it for subsequent assembly of 7SK RNP.
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