Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3
August 27th, 2018 by Yuan Fu
Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3
Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3, Published online: 27 August 2018; doi:10.1038/s41589-018-0113-5
The large subunit of ribonucleotide reductase RNR-α downregulates DNA replication in the nucleus by directly disrupting PCNA and ZRANB3 interactions. RNR-α nuclear entry is regulated by an interplay between IRBIT and importin-α1.