Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3

August 27th, 2018 by Yuan Fu

Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3

Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3, Published online: 27 August 2018; doi:10.1038/s41589-018-0113-5

The large subunit of ribonucleotide reductase RNR-α downregulates DNA replication in the nucleus by directly disrupting PCNA and ZRANB3 interactions. RNR-α nuclear entry is regulated by an interplay between IRBIT and importin-α1.
  • Posted in Nat Chem Biol, Publications
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