Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation

August 19th, 2019 by Young-Chan Kim

Nature Chemical Biology, Published online: 19 August 2019; doi:10.1038/s41589-019-0344-0

Inhibition of fatty acid synthase, FASN, blocks innate immune signaling through TLR/MyD88 in neutrophils by blocking palmitoylation of MyD88 by palmitoyltransferase zDHHC6 and improves outcomes in two mouse models of sepsis.
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