Structural biology: A ‘funny’ cyclic dinucleotide receptor

May 16th, 2014 by Yoni Haitin

Nature Chemical Biology 10, 413 (2014). doi:10.1038/nchembio.1530

Author: Yoni Haitin

Deciphering the molecular basis of HCN channel regulation by cGMP leads to the serendipitous discovery of cyclic dinucleotides as potent inhibitors of If current in the heart.