Dual phenazine gene clusters enable diversification during biosynthesis

March 18th, 2019 by Yi-Ming Shi

Dual phenazine gene clusters enable diversification during biosynthesis

Dual phenazine gene clusters enable diversification during biosynthesis, Published online: 18 March 2019; doi:10.1038/s41589-019-0246-1

Enzymes from two discrete biosynthetic gene clusters in the entomopathogenic bacterium Xenorhabdus szentirmaii cooperate to produce a diverse array of phenazine natural products, including phenazine–peptide and phenazine–polyketide derivatives.
  • Posted in Nat Chem Biol, Publications
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Microbiology: A new language for small talk

April 13th, 2017 by Yi-Ming Shi

Nature Chemical Biology 13, 453 (2017). doi:10.1038/nchembio.2362

Authors: Yi-Ming Shi & Helge B Bode

A new signal–receptor pair involved in regulating biofilm formation and virulence was detected in Vibrio cholerae. Both the signal and the transcription factor belong to common classes of natural products and receptor proteins, suggesting widespread importance of related systems in nature.