Antibody-free enzyme-assisted chemical approach for detection of <i>N</i><sup>6</sup>-methyladenosine

April 27th, 2020 by Ye Wang

Nature Chemical Biology, Published online: 27 April 2020; doi:10.1038/s41589-020-0525-x

An antibody-independent m6A profiling method called m6A-SEAL was developed via turning m6A into stable dm6A after treatment by FTO and DTT. This method exhibits better reliability in detection of transcriptome-wide m6A sites in humans and plants.
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