Synthetic yeast brews neuroactive compounds

October 28th, 2020 by Yang Gu

Nature Chemical Biology, Published online: 28 October 2020; doi:10.1038/s41589-020-00691-5

Metabolic engineering offers the flexibility to meet market demand for bioactive natural products but can be hampered when a necessary protein or intermediate is toxic. In yeast, modifying the subcellular localization of biosynthetic enzymes can alleviate toxicity and increase production titer.