Mammalian signaling circuits from bacterial parts

December 16th, 2019 by Xiaoyu Yang

Nature Chemical Biology, Published online: 16 December 2019; doi:10.1038/s41589-019-0436-x

The ability to engineer synthetic signaling networks has proven challenging for synthetic biology. A breakthrough design strategy shows that bacterial two-component-system-derived parts can be grafted into mammalian cells to create programmable phosphorylation circuitry.