Molecular basis for ubiquitin ligase CRL2<sup>FEM1C</sup>-mediated recognition of C-degron

January 4th, 2021 by Xiaojie Yan

Nature Chemical Biology, Published online: 04 January 2021; doi:10.1038/s41589-020-00703-4

Crystal structures of FEM1C in apo and in complex with a C-degron ending with arginine reveal a binding pocket in FEM1C that recognizes C-degrons and the essential role of C-terminal arginine for recognition.
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