A lanthipeptide library used to identify a protein–protein interaction inhibitor

March 5th, 2018 by Xiao Yang

A lanthipeptide library used to identify a protein–protein interaction inhibitor

A lanthipeptide library used to identify a protein–protein interaction inhibitor, Published online: 05 March 2018; doi:10.1038/s41589-018-0008-5

The substrate-tolerant lanthipeptide synthetase ProcM enables the construction of a plasmid-encoded library of bicyclic lanthipeptides, from which an inhibitor of the p6–UEV protein–protein interaction is identified by a reverse two-hybrid screen.
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