Programmable RNA <i>N</i><sup>6</sup>-methyladenosine editing by CRISPR-Cas9 conjugates

August 5th, 2019 by Xiao-Min Liu

Nature Chemical Biology, Published online: 05 August 2019; doi:10.1038/s41589-019-0327-1

Fusion of Cas9 with m6A writers METTL3 and METTL14 or eraser ALKBH5 enables site-specific writing or erasing of RNA m6A modifications in mammalian cells and investigation of individual m6A modification-mediated function.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on Programmable RNA <i>N</i><sup>6</sup>-methyladenosine editing by CRISPR-Cas9 conjugates