CX3CR1 (+) B cells show immune suppressor properties [Cell Biology]

June 26th, 2014 by Wu, Z.

The immune regulatory functions of B cells are not fully understood yet. The present study aims to characterize a subtype of B cells which expresses CX3CR1. Peripheral blood samples were collected from patients with food allergy (FA) and healthy subjects. Peripheral B cells were analyzed by flow cytometry. T cell proliferation was assessed by carboxyfluorescein succinimidyl ester-dilution assay. The results showed that the CX3CR1+ B cells were detected in the peripheral blood samples of healthy subjects, which were significantly less in patients with FA. CX3CR1+ B cells expressed high levels of transforming growth factor (TGF)-β and alpha v beta 6 (avb6). CX3CR1+ B cells could efficiently suppress other effector CD4+ T cell activation. Human peripheral CX3CR1+ B cells have immune suppressor property.