Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision

May 17th, 2019 by Woo-Chan Ahn

Nature Chemical Biology, Published online: 17 May 2019; doi:10.1038/s41589-019-0289-3

Structural analysis of uracil DNA glycosylases in complex with DNA reveals that conserved H109 acts as a nucleophile to attack the oxocarbenium ion and makes a covalent bond to the abasic site after uracil excision to form a stable intermediate.
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