Drug development: Locking down metabolism
August 18th, 2017 by William R Bishai
Nature Chemical Biology 13, 925 (2017). doi:10.1038/nchembio.2452
Author: William R Bishai
An allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase—an enzyme that is nonessential for in vitro growth—has potent antimicrobial activity, revealing a potentially expanded target list for antimicrobials and greater chemical space for new inhibitors.