Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis

November 25th, 2019 by William B. Black

Nature Chemical Biology, Published online: 25 November 2019; doi:10.1038/s41589-019-0402-7

Redesign of a glucose dehydrogenase to use nicotinamide mononucleotide (NMN+) instead of NAD(P)+ enables the development of a noncanonical cofactor system that can be used to support redox chemistries both in vitro and in Escherichia coli.
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