S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

July 22nd, 2019 by Wei Qin

Nature Chemical Biology, Published online: 22 July 2019; doi:10.1038/s41589-019-0323-5

Using a thiol-reactive probe, chemoproteomic profiling of cysteine targets of itaconate reveals the covalent modification of glycolytic enzymes, impairing glycolytic flux and contributing to attenuation of the inflammatory response in macrophages.
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