Immunology: JAK3 inhibition—is it sufficient?

April 19th, 2015 by Warren J Leonard

Nature Chemical Biology 12, 308 (2016). doi:10.1038/nchembio.2066

Authors: Warren J Leonard, Suman Mitra & Jian-Xin Lin

A highly selective JAK3 inhibitor with subnanomolar potency has been used to identify two waves of STAT5 phosphorylation in response to IL-2. This reveals a biphasic role for JAK3 catalytic activity in IL-2-mediated signaling that has therapeutic implications.