Unraveling the rewired network

June 25th, 2018 by Vinayak Palve

Unraveling the rewired network

Unraveling the rewired network, Published online: 25 June 2018; doi:10.1038/s41589-018-0083-7

Adaptive survival signaling can promote resistance to individual kinase inhibitors. A new study used a pathway-based approach to characterize shared kinome-wide rewiring mechanisms across multiple kinase inhibitors and developed rational drug-combination approaches that target cross-talk between two signaling pathways.